ACETYLTRANSFERASE (PLATELET-ACTIVATING FACTOR SYNTHESIS) ACTIVITY OF NEUTROPHILS IN INFLAMMATORY DISORDERS: EFFECTS OF CYTOKINES INCLUDING TUMOR NECROSIS FACTOR.
ACETYLTRANSFERASE (PLATELET-ACTIVATING FACTOR SYNTHESIS) ACTIVITY OF NEUTROPHILS IN INFLAMMATORY DISORDERS: EFFECTS OF CYTOKINES INCLUDING TUMOR NECROSIS FACTOR.
批准号:
63571105
负责人:
OZAKI Yukio
金额:
$1.34万
依托单位国家:
日本
项目类别:
Grant-in-Aid for General Scientific Research (C)
财政年份:
1988
资助国家:
日本
项目状态:
已结题
起止时间:
1988 至 1989
中文摘要
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英文摘要
Of the five cytokines tested (tumor necrosis factor, interleukin 1, colony-stimulating factor, interferon alpha, beta, and gamma), only tumor necrosis factor (TNF) showed a potent stimulatory effect on the acetyltransferase activity of human neutrophils, which is a key enzyme for the production of platelet-activating factor. This potentiating effect of TNF was time- and dose-dependent and could be effectively blocked by antiserum against TNF. None of Intracellular Ca^<++> elevation, protein kinase C activation, and arachidonic acid metabolites appeared to be involved in the TNF-induced potentiation of the acetyltransferase activity in neutrophils, and the mechanism of TNF potentiation remains to be clarified.
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Yukio Ozaki,Yuki Matsumoto,Yutaka Yatomi,Toshitsugu Kariya,and Shoji Kume: "Acetyltransferase activity and production of platelet-activating factor by human neutrophils activated by various stimuli." Acta Haematologica Japonica. 52(4). 696-706 (1989)
Yukio Ozaki、Yuki Matsumoto、Yutaka Yatomi、Toshitsugu Kariya 和 Shoji Kume:“各种刺激激活的人中性粒细胞的乙酰转移酶活性和血小板激活因子的产生。”
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Yukio Ozaki,Yuki Matsumoto,Yutaka Yatomi,Toshitsugu Kariya,and Shoji Kume: "Acetyltransferase activity and production of platelet-activating factor by human neutrophils activated by various stimuli." Acta Haematologica Joponica. 52(4). 696-706 (1989)
Yukio Ozaki、Yuki Matsumoto、Yutaka Yatomi、Toshitsugu Kariya 和 Shoji Kume:“各种刺激激活的人中性粒细胞的乙酰转移酶活性和血小板激活因子的产生。”
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Yukio Ozaki, Toshio Oyama, Yuki Matsumoto, and Shoji Kume: Yamanashi Medical Journal.
Yukio Ozaki、Toshio Oyama、Yuki Matsumoto 和 Shoji Kume:山梨医学杂志。
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Yukio Ozaki;Yuki Hatsumoto;Yutaka Yatomi;Toshitsugu Kariya;Shoji Kume: Acta Haematologica Japonica. (1989)
尾崎由纪夫;初本由纪;矢富裕;刈谷敏嗣;久米正司:日本血液学学报。
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Yukio Ozaki,Toshio Oyama,Yuki Matsumoto,and Shoji Kume: "Tumor necrosis factor stimulates acetyltransferase activity of human neutrophils." Yamanashi Medical Journal.
Yukio Ozaki、Toshio Oyama、Yuki Matsumoto 和 Shoji Kume:“肿瘤坏死因子刺激人类中性粒细胞的乙酰转移酶活性。”
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