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EFFECTS OF EXERCISE ON PREVENTION AND TREATMENT OF OBESITY - ENERGY, PROTEIN AND CHOLESTEROL METABOLISM

运动对预防和治疗肥胖的影响 - 能量、蛋白质和胆固醇代谢

基本信息

批准号：
63580063
负责人：
OKUDA Toyoko
金额：
$ 1.47万
依托单位：
OSAKA CITY UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1989
项目状态：
已结题

项目摘要

The effects of voluntary exercise by rats on body weight gain, blood status, the weight of adipose tissue and body composition were investigated. Young male rats were housed so as to keep them sedentary or else given free access to a running wheel for 3 or for 11 weeks. In rats that ate ad libitum (feed containing 25% fat), voluntary running had a circadian rhythm. Voluntary running did not affect body weight gain or blood status, but it decreased the weight of adipose tissue and liver lipid and body lipid concentrations. This suggested that voluntary running had the effect of helping to prevent obesity in the young eats.In adult rats, the effects of voluntary exercise and dietary restriction on the treatment of obesity for 4 weeks were studied. The group restricted in its were fed 60% of the mean amount eaten the previous day by another group fed ad libitum. The feed contained 5% fat. During the study, the restricted- diet group not allowed to exercise gained 12% of its initial level of body protein, but lost 38% of body lipids and 6% of body weight. This 60% restricted diet was effective in the treatment of obesity in adult rats. In the rats allowed to exercise but restricted in their diet, the amount of exercise was greater than in rats fed ad libitum and allowed to exercise. Their circadian rhythm was disrupted and they lost 38% of initial body weight, 32% of initial body protein and 89% of initial body lipids. Thus, body lipids were used effectively as an energy source. However, the rats allowed to exercise but restricted in diet developed anemia, low plasma albumin levels, loss of protein from the liver and loss of body protein. This suggested that diet restriction coupled with voluntary exercise was effective for the treatment of obesity, but it seems that the percentage of restriction should be somewhat increased.

研究了自愿运动对大鼠体重增加、血液状况、脂肪组织重量和体成分的影响。年轻的雄性老鼠被关在笼子里，让它们久坐不动，或者在3周或11周内自由进入跑步轮。在随意进食（含25%脂肪的饲料）的大鼠中，自愿跑步具有昼夜节律。自愿跑步不影响体重增加或血液状况，但它降低了脂肪组织的重量、肝脏脂质和体脂浓度。这表明，自愿跑步有助于防止年轻人肥胖。在成年大鼠中，研究了自愿运动和饮食限制对肥胖治疗的影响，为期4周。限食组按前一天平均食量的60%饲喂，另一组自由饲喂。饲料中脂肪含量为5%。在研究期间，不允许运动的限制饮食组的身体蛋白质增加了12%，但血脂下降了38%，体重下降了6%。这种60%的限制饮食对成年大鼠的肥胖治疗有效。在允许运动但限制饮食的大鼠中，运动量大于自由喂养并允许运动的大鼠。他们的昼夜节律被打乱，他们失去了38%的初始体重，32%的初始身体蛋白质和89%的初始身体脂质。因此，身体脂质被有效地用作能量来源。然而，允许运动但限制饮食的大鼠出现了贫血、血浆白蛋白水平低、肝脏蛋白质损失和体内蛋白质损失。这表明，饮食限制加上自愿运动对治疗肥胖是有效的，但似乎限制的比例应该有所增加。