The effects of soy protein isolate on plasma cholesterol

大豆分离蛋白对血浆胆固醇的影响

• 批准号: 60580069
• 负责人: OKUDA Toyoko
• 金额: $ 1.34万
• 依托单位: Osaka City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60580069/
• 关键词: Soy protein isolate; Casein; cholesterol; Plasma cholesterol; Fecal cholesterol; Xeutral sterol; Fecal sterol; カゼイン; 分離大豆蛋白質; 中性コレステロール; 血漿脂質; 消化吸収率

1. The effects of soy protein isolate (SPI) on the cholesterol concentration in plasma of young rats. Plasma cholesterol tended to be lower in rats fed SPI than in those fed the whole egg protein or casein. 2. The rats fed the SPI diet without cholesterol after the 2 weeks on the high-cholesterol casein diet tended to recover more rapidly from hypercholesterolemia and hepatic hypertrophy than those fed a casein diet without cholesterol. The SPI diets with or without cholesterol caused significantly more lipids and neutral sterols to be excreted in the feces than either of the casein diet. These data suggest that the incresed excretion of fecal neutral sterol may in part account for the hypocholesterolemic effect of soy protein. 3. The effects of the substitution of soy protein isolate for milk protein in diets on plasma cholesterol levels and fecal neutral sterol excretion, were examined on 10 healthy young men. During the milk diet period, total and LDL-cholesterol levels and atherogenic index were significantly increased, but they were unchanged during the SPI diett period. However, there were no differences of plasma glucose, insulin, glucagon and fecal sterol excrretion in the both diets.

1.大豆分离蛋白对幼鼠血浆胆固醇浓度的影响。血浆胆固醇往往是较低的大鼠饲料SPI比那些喂养全蛋蛋白或酪蛋白。2.在高胆固醇酪蛋白饮食2周后，喂食不含胆固醇的SPI饮食的大鼠比喂食不含胆固醇的酪蛋白饮食的大鼠更快地从高胆固醇血症和肝肥大中恢复。与酪蛋白饮食相比，含或不含胆固醇的SPI饮食导致粪便中排泄的脂质和中性固醇显著更多。这些数据表明，粪便中性固醇排泄量的增加可能是大豆蛋白降低胆固醇作用的部分原因。3.本文观察了10名健康青年男子用大豆分离蛋白替代乳蛋白对血浆胆固醇水平和粪便中性固醇排泄量的影响。在牛奶饮食期间，总胆固醇和LDL-胆固醇水平以及致动脉粥样硬化指数显著增加，但在SPI饮食期间它们没有变化。而血糖、胰岛素、胰高血糖素和粪固醇排泄量在两种日粮中无差异。

项目成果

奥田豊子: 大阪市立大学 生活科学部 紀要. 34. (1986)

奥田丰子：大阪市立大学生命科学学院通报34。（1986）

奥田豊子,山本由美子,三好弘子,尾井百合子,小石秀夫: 阪市大生科紀要. 35. (1987)

Toyoko Okuda、Yumiko Yamamoto、Hiroko Miyoshi、Yuriko Oi、Hideo Koishi：大阪市立大学医学院通报 35。（1987）。

奥田豊子: 日本家政学会第38回大会研究発表要旨集. 68 (1986)

奥田丰子：日本家政学会第 38 届年会研究报告摘要集 68 (1986)。

Toyoko Okuda; Reiko Higashinaka; Hiroko Miyoshi; Hideo Koishi: "The effects of the soy protein isolate on cholesterol concentration in plasma of rats" Annual Report of the Sciences of Living, Osaka City University. 34. 17-22 (1986)

奥田丰子；

Toyoko Okuda; Yumiko Yamamoto; Hiroko Miyoshi; Yuriko Oi; Hideo Koishi: "Effects of soy protein isolate on recovery from hypercholesterolemia and fatty liver of rats" Annual Report of the Sciences of Living, Osaka City University. 35. (1987)

奥田丰子；