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The roles of protein nutrition and exercise on prevention of osteoporosis

蛋白质营养和运动对预防骨质疏松症的作用

基本信息

批准号：
07680036
负责人：
OKUDA Toyoko
金额：
$ 1.47万
依托单位：
OSAKA KYOIKU UNIVERSITY (1996)Osaka City University (1995)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07680036/
关键词：
osteoporosis bone mass bone mineral content bone breaking force low protein diet high protein die exercise Ca absorption コラーゲンペプチド分離大豆タンパク質タンパク質欠乏骨カルシウム濃度成長期ラット奥田豊子

项目摘要

Osteoporosis is a disease characterised by low bone mass excessive loss of minerals and protein contents in bone. For the prevention of osteoporosis, factors affecting lifestyle such as diet or physical activity are important. The effects of protein intake, dietary protein of different sources and voluntary running exercise on mineral utilization by the body and bone metabolism in the femur were investigated in growing male rats and adult ovaritectomized (OVX) rats. The apparent intestinal absorption of Ca, P,and Mg and their retention by the body increased linearly with dietary concentrations of 5,10,20, and 30% casein diet in growing male rats. Hence, dietary protein deprivation resulted in slow bone growth and weak bone strength. These findings indicated that protein intake during the crucial years of peak bone mass development is important for the prevention of osteoporosis.Although Ca excretion in urine is known to be directly correlated with the level of dietary protein intake, t … More he effects of excess dietary protein intake on bone metabolism is nuclear. The effects of high protein diets of different sources, 25% casein, 50% casein, 50% soy protein isolate (SPI), 25% casein+25% collagen peptide (LCP), and 25% SPI+25%LCP,on bone metabolism was studied in OVX rats for 12 weeks. Exercise groups were set up in each of those groups that were fed diets cotaining LCP.The different protein sources and exercise had no effect on food intake, body fat, and final body weight. Although increasing the level of dietary protein from 25% to 50% in OVX rats caused a tenfold increase in urinary Ca, there were no differences in Ca retention and weight, Ca content, and breaking force of femur. Weight, Ca, and Mg contents of the femur in the groups fed on diet containing LCP were significantly higher than those in the groups fed on casein and SPI.The breaking force of the femur and humerus in these groups were higher than those in the groups fed on casein and SPI.These results suggest that although excess protein intake exerted a significant calciuretic effect, in rats, the amount of Ca excretion in the urine was very small and has little small effect on bone metabolism. Collagen peptide has some effect on bone metabolism. Less

骨质疏松症是一种以骨量低、骨骼中矿物质和蛋白质含量过多流失为特征的疾病。为了预防骨质疏松症，影响生活方式的因素，如饮食或体育活动是很重要的。研究了生长雄性大鼠和去卵巢（OVX）成年大鼠蛋白质摄入、不同来源的膳食蛋白质和自主运动对机体矿物质利用和股骨骨代谢的影响。生长期雄性大鼠肠道钙、磷、镁的表观吸收量和体内钙、磷、镁的滞留量随饲粮中酪蛋白浓度为5%、10%、20%和30%呈线性增加。因此，饮食中蛋白质的缺乏导致骨骼生长缓慢，骨骼强度弱。这些发现表明，在骨量高峰发育的关键时期摄入蛋白质对预防骨质疏松症很重要。虽然已知钙在尿中的排泄与膳食蛋白质摄入水平直接相关，但更多的是，过量膳食蛋白质摄入对骨代谢的影响是核心的。研究了25%酪蛋白、50%酪蛋白、50%大豆分离蛋白（SPI）、25%酪蛋白+25%胶原肽（LCP）、25%大豆分离蛋白+25%LCP高蛋白饲料对OVX大鼠骨代谢的影响。在每组中都设置了运动组，每组的饮食中都含有LCP。不同的蛋白质来源和运动对食物摄入量、体脂和最终体重没有影响。虽然将OVX大鼠的膳食蛋白质水平从25%增加到50%会导致尿钙增加10倍，但在钙潴留和重量、钙含量和股骨断裂力方面没有差异。LCP组股骨重量、Ca、Mg含量显著高于酪蛋白组和SPI组。这些组股骨和肱骨的断裂力均高于酪蛋白和SPI喂养组。上述结果提示，虽然过量蛋白质摄入对大鼠有明显的钙化作用，但大鼠尿液中钙的排泄量非常少，对骨代谢的影响很小。胶原肽对骨代谢有一定的影响。少