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Development of a Reduced Energy type Implantable Defibrillator.

低能量型植入式除颤器的开发。

基本信息

批准号：
01550306
负责人：
ISHII Ikuo
金额：
$ 1.54万
依托单位：
Faculty of Engineering, Niigata University.
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1989
资助国家：
日本
起止时间：
1989 至 1990
项目状态：
已结题

项目摘要

1) Development of arrhythmia detection methodTo develop a new arrhythmia detection method, we used the interval histogram method for ECG, and we made an on-line real time detection program to analyze the frequency variation of the ECG. After that, we installed the program into a battery-type arrhythmia detection circuit, and confirmed its function. In the prior use of the implantable defibrillator, the probability density function was the only method used due to the limitation of power consumption and circuitry. However, as our method can detect the basic frequency components in real time and with smaller circuitry, it is beneficial to separate arrhythmia more accurately.2) Development of an implantable defibrillatorThe arrhythmia detection circuit and the output circuit were developed. The detection circuit was used to execute our method, and the output circuit has the capability of sequential stimulation which is effective to reduce the defibrillation energy. In our stimulation metho … More d, the voltage of the second stimulation pulse is less than the first pulse because of the simple circuit. However, it is easy for an ordinary single output defibrillator to be modified to a sequential defibrillator by simple improvement of the output circuitry. At the same time, there was no difference in the defibrillation voltage threshold between our system and an external type sequential defibrillator. Therefore, this stimulation method is hopeful due to its smaller size and lower defibrillation energy circuit.3) Experimental resultsIn animal experiments, we confirmed the function of the arrhythmia detection circuit and the output circuit. As a result, we proposed the basic design of a lower energy implantable defibrillator.In the future, we will combine a database which contains various ECG data with the detection program to develop a personal oriented detection system. Moreover, we will also make all effort to seal the new implantable system for use in chronic animal experiments. Less

1)心律失常检测方法的发展为了发展一种新的心律失常检测方法，我们采用了心电图的间期直方图法，并编制了一个在线的真实的时间检测程序，对心电图的频率变化进行分析。然后将该程序安装到电池型心律失常检测电路中，并对其功能进行了验证。在植入式除颤器的先前使用中，由于功耗和电路的限制，概率密度函数是唯一使用的方法。但由于本方法能真实的实时检测出基频成分，且电路体积小，有利于更准确地分离心律失常。2）植入式心律失常发生器的研制了心律失常发生器的检测电路和输出电路。检测电路用于执行我们的方法，输出电路具有顺序刺激的能力，这是有效地减少除颤能量。在我们的刺激方法中， ...更多信息 d.由于电路简单，第二刺激脉冲的电压小于第一脉冲。然而，通过简单地改进输出电路，普通的单输出除颤器很容易被修改为顺序除颤器。同时，我们的系统和外部型顺序除颤器之间的除颤电压阈值没有差异。因此，这种刺激方法由于其体积小、除颤能量低，是有希望的。3）实验结果在动物实验中，我们证实了心律失常检测电路和输出电路的功能。因此，我们提出了一个低能量植入式除颤器的基本设计，未来我们将联合收割机的数据库，包含各种心电数据和检测程序相结合，开发一个面向个人的检测系统。此外，我们还将尽一切努力密封新的植入式系统，用于慢性动物实验。少