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The study on the role of fluoride in the formation of urinary calculi

氟化物在泌尿系结石形成中作用的研究

基本信息

批准号：
01570886
负责人：
KATO Takahiro
金额：
$ 1.41万
依托单位：
Mie University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1989
资助国家：
日本
起止时间：
1989 至 1991
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01570886/
关键词：
Fluorosis Urolithiasis Thailand 弗素食事調査尿路結石弗素化合物

项目摘要

There are many urinary stone patients in the northern part of Thailand and we have seen these patients having bone fluorosis on X-ray.This time we were able to determine fluorine concentration of the drinking water and the urine of 61 urolithiasis patients in the northern part of Thailand under cooperation with Prof. V. Choomsai and prof. S. Wudhikarn. Mean age of 61 patients was 52.2 year-old. Thirty-nine patients were male and 22 patients were female. Ten patients (16.4%) in these patients had bone fluorosis on X-ray. Eight patients were male and 2 patients were female. The fluorine concentration of drinking water in 61 patients was 0.36 mg per liter. The fluorine concentration of urine in these patients was 1.02 mg per liter. The fluorine concentration of drinking water in 10 patients with bone changes was 0.81 mg per liter. The fluorine concentration of urine in these patients was 1.84 mg per liter. There was no significance between the patients with bone changes and without bone changes.We analyzed 12 urinary stones in 61 patients by using infrared analyzer. Calcium oxalate stones were 2, magnesium ammonium phosphate stones were 3, calcium oxalate and calcium phosphate stones were 5, and calcium oxalate and other's stones were 2. We analyzed 2 stones of Thai patients and 2 stones of Japanese patients by Electron Probe Micro Analyzer, X-ray Analyzer and Polarized Microscope.The urinary stone formation in northern Thailand seemed to be related to their foods and the state of sanitation and bone fluorosis to be the effect of the fluorine intake from foods and drinking water.We appreciate the helpful kindness of Prof. Vorvat Choomsai and Prof. Supot Wudhikarn, Division of Urology, Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

在泰国北方有许多泌尿系统结石患者，我们在X光片上看到这些患者患有氟骨症。这次我们与V. Choomsai教授和S.武迪肯61例患者的平均年龄为52.2岁。39例患者为男性，22例患者为女性。X线片显示氟骨症10例（16.4%）。男性8例，女性2例。61例患者饮水氟浓度为0.36mg/L。尿氟浓度为1.02mg/L。10例骨改变患者饮水氟浓度为0.81mg/L。尿氟浓度为1.84mg/L。应用红外光谱分析仪对61例12枚泌尿系结石进行了分析。草酸钙结石2例，磷酸铵镁结石3例，草酸钙和磷酸钙结石5例，草酸钙和其他结石2例。我们用电子探针显微分析仪、X线分析仪和偏光显微镜分析了2例泰国患者和2例日本患者的尿结石，泰国北方的尿结石形成似乎与他们的食物和卫生状况有关，骨氟中毒是从食物和饮用水中摄入氟的影响，我们感谢Vorvat Choomsai教授和Supot Wudhikarn教授的帮助，泰国清迈，清迈大学医学院外科泌尿科。