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Brain Control of the Reproductive System

大脑对生殖系统的控制

基本信息

批准号：
02305004
负责人：
YOKOYAMA Akira
金额：
$ 6.78万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Co-operative Research (A)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1991
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02305004/
关键词：
Brain Reproduction Neuroendocrinology Central Nervous System Environment Physiology Morphology

项目摘要

The purpose of the present research group is to elucidate the location of the pulse generator, which is thought to regulate the pulsatile release of luteinizing hormone (LH) through the pulsatile LH releasing homone (LHRH) release, in the hypothalamus and to make clear the regulatory mechanism of the pulse generator. That oxytocin is released in a pulsatile manner in spite of the continous stimulus to the teat by pups has been well established. Therefore, a search for the location of the LHRH pulse generator is also one of the purposes of this research group.The presence of the LH pulse generator in the medial basal hypothalamus (MBH) in rats and shiba goats has been demonstrated by the following experiments : 1) Complete deafferentation of the hypothalamus in the rat ; 2) Transplantation of the fetal median eminence (EM) into the adult female rat in which the pulsatile LH secretion was blocked by electrolytic lesions made in the anterior part of the arculate nucleus in rats ; 3) In vi … More tro intra-arterial perfusion of the rat's hypothalamus ; 4) Multiple unit activities (MUA) recording from the arcuate nucleus in shiba goats. An attempt was made to record the single unit activity from the LHRH cell projecting its axon to the ME.However, the activity was recorded only from a small number of cells and we can not tell whether the LHRH cells themselves generates the pulsatility. Burst discharges of OT cells in the supra optic and paraventricular nuclei were recorded intermittently in the rat suckled continously by pups.We found several neurones fired synchronously with OT cells in the dorsomedial hypothalamic nucleus. Although these neurones send axons to the supra optic nucleus, no projection of these cells to the posterior lobe of the pituitary is found. Therefore, the possibility exists that these cells transform the continuous impulse emanating from the teat to the intermittent information causing the pulsatile secretion of OT. Relationship between these cells and the LHRH pulse generator is remained unsolved. Less

本课题组的目的是阐明脉冲发生器在下丘脑中的位置，脉冲发生器被认为通过脉动性黄体生成素(LHRH)的释放来调节黄体生成素(LHRH)的脉动性释放，并阐明脉冲发生器的调节机制。尽管幼崽对乳头的持续刺激，催产素是以脉动的方式释放的，这一点已经得到了很好的证实。因此，寻找促黄体生成素脉冲发生器的位置也是本研究小组的目的之一。下列实验证明了下丘脑内侧基底核存在促黄体生成素脉冲发生器：1)大鼠下丘脑完全去传入；2)将胎儿正中隆起(EM)移植到成年雌性大鼠体内，在成年雌性大鼠的弓状核前部造成电解损伤，阻断黄体生成素的搏动性分泌；3)在vi…更多地经动脉灌注大鼠下丘脑；4)柴胡山羊弓状核多单位活动(MUA)的记录。有人试图记录LHRH细胞从轴突投射到ME的单个单位活动，但这种活动只记录了一小部分细胞，我们不能确定LHRH细胞本身是否产生了脉动性。在连续哺乳的大鼠视上核和室旁核，间歇性地记录到催产素细胞的突发性放电，在下丘脑背内侧核发现有多个神经元与催产素细胞同步放电。虽然这些神经元将轴突发送到视上核，但没有发现这些细胞向垂体后叶投射。因此，这些细胞有可能将乳头发出的连续冲动转化为引起催产素搏动性分泌的间歇性信息。这些电池与LHRH脉冲发生器之间的关系仍未解决。较少