Fibroblast-dependent Proliferation of Mast Cells
肥大细胞成纤维细胞依赖性增殖
基本信息
- 批准号:02404030
- 负责人:
- 金额:$ 20.61万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (A)
- 财政年份:1990
- 资助国家:日本
- 起止时间:1990 至 1993
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Fibroblast-dependent proliferation of mast cells is mediated by stem cell factor (SCF) produced by fibroblasts and c-kit receptor (KIT) expressed on the surface of mast cells. Ws studied the SCF-KIT system from various viewpoints and obtained the following results. 1). Although many KIT mutants have been found in mice, KIT mutants were not known in rats. We described the first KIT mutants in rats. We characterized the Ws (White spotting) locus of rats which encoded the KIT.2). We compared the molecular nature of murine KIT mutants with the number of mast cells in thier skin. 3). We studied the unique KIT mutation designated as Wsh. Although the Wsh mutant allele is located at the W locus, we could not find any abnormalities in the coding region of KIT gene. Since KIT was not transcribed in cultured mast cells derived from the bone marrow of Wsh/Wsh mice, the Wsh mutation was considered to be a mutation at the regulatory region. Since KIT was transcribed in erythroblasts and germ cells of Wsh/Wsh mice, the abnormality of KIT transcription appeared to be cell type specific. Moreover, we found the KIT transcription was influenced by the age in mast cells of Wsh/Wsh mice. Although an appreciable number of mast cells was found in the skin of Wsh/Wsh embryos, mast cells decreased rapidly after birth due to the abolishment of KIT transcription. 4). The mi locus of mice encodes a transcription factor of basic helix-loop-helix leucine zipper family. We demonstrated that the phenotypic abnormalities observed in mast cells of mi/mi mice was attributable to the deficeint transcription of various proteins.
肥大细胞的成纤维细胞依赖性增殖由成纤维细胞产生的干细胞因子(SCF)和肥大细胞表面表达的c-kit受体(KIT)介导。Ws从各种观点研究了SCF-KIT系统,并获得了以下结果。1)。尽管在小鼠中发现了许多KIT突变体,但在大鼠中还不知道KIT突变体。我们在大鼠中描述了第一个KIT突变体。我们描述了编码KIT的大鼠的Ws(白色斑点)位点。我们比较了小鼠KIT突变体的分子性质与其皮肤中肥大细胞的数量。3)。我们研究了被命名为Wsh的独特KIT突变。虽然Wsh突变等位基因位于W位点,但我们在KIT基因编码区未发现任何异常。由于KIT在来源于Wsh/Wsh小鼠骨髓的培养肥大细胞中不转录,因此认为Wsh突变是调控区的突变。由于KIT在Wsh/Wsh小鼠的成红细胞和生殖细胞中转录,因此KIT转录异常似乎具有细胞类型特异性。此外,我们还发现Wsh/Wsh小鼠肥大细胞中KIT的转录受年龄的影响。虽然在Wsh/Wsh胚胎的皮肤中发现了相当数量的肥大细胞,但由于KIT转录的废除,肥大细胞在出生后迅速减少。4)。小鼠mi基因座编码碱性螺旋-环-螺旋亮氨酸拉链家族的转录因子。我们证明,在mi/mi小鼠肥大细胞中观察到的表型异常可归因于多种蛋白质的转录缺陷。
项目成果
期刊论文数量(42)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Kasugai,Tsutomu: "Deficient differentiation of mast cells in the skin of mi/mi mice : usefulness of in situ hybridization for evaluation of mast cell phenotype." American Journal of Pathology. 143. 1337-1347 (1993)
Kasugai,Tsutomu:“mi/mi 小鼠皮肤中肥大细胞分化缺陷:原位杂交在评估肥大细胞表型方面的用途。”
- DOI:
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- 影响因子:0
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Hirata,Tatsumi: "Stem cell factor induces outgrowth of c-kit-positive neurites and supports the survival of c-kit-positive neurons in DRG" Development. 119. 49-56 (1993)
Hirata, Tatsumi:“干细胞因子诱导 c-kit 阳性神经突生长,并支持 DRG 中 c-kit 阳性神经元的存活”。
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- 影响因子:0
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Arizono,Naoki: "Infection of N.brasiliensis induces development of mucosal-type but not connective tissue-type mast cells in Ws/Ws rats" Blood. 81. 2572-2578 (1993)
Arizono,Naoki:“巴西 N.brasiliensis 的感染会诱导 Ws/Ws 大鼠粘膜型肥大细胞的发育,但不会诱导结缔组织型肥大细胞的发育”血液。
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- 影响因子:0
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Jozaki,K.: "Proliferative potential of murine peritoneal mast cells after degranulation induced by compound 48/80,Substance P,tetraーdecanoylphorbol acetate,or calcium ionophore A23187." Journal of Immunology. 145. 4252-4259 (1990)
Jozaki, K.:“化合物 48/80、P 物质、乙酸十四烷酰佛波醇或钙离子载体 A23187 诱导的小鼠腹膜肥大细胞的增殖潜力。免疫学杂志 145。4252-4259”。
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- 影响因子:0
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Jozaki,K.: "Bone marrowーderived cultured mast cells and peritoneal mast cells as target of a growth activity secreted by BALB/3T3 fibroblasts." Experimental Hematology.
Jozaki, K.:“骨髓来源的培养肥大细胞和腹膜肥大细胞作为 BALB/3T3 成纤维细胞分泌的生长活性的目标。”
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KITAMURA Yukihiko其他文献
KITAMURA Yukihiko的其他文献
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{{ truncateString('KITAMURA Yukihiko', 18)}}的其他基金
Regulation of Mast Cell Differentiation by mi Transcription Factor (MITE)
mi 转录因子 (MITE) 对肥大细胞分化的调节
- 批准号:
12002010 - 财政年份:2000
- 资助金额:
$ 20.61万 - 项目类别:
Grant-in-Aid for Specially Promoted Research
Analysis of Phenotypic Variation of Mast Cells by Using Messenger RNA Expression as a Marker
以信使 RNA 表达为标志物分析肥大细胞表型变异
- 批准号:
06454193 - 财政年份:1994
- 资助金额:
$ 20.61万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
Regulation of Hemopoietic Stem Cells and Its Clinical Application
造血干细胞的调控及其临床应用
- 批准号:
06277103 - 财政年份:1994
- 资助金额:
$ 20.61万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
Development of Mutant Rats Useful for Analysis of Immediate Hypersensitivity
可用于速发型超敏反应分析的突变大鼠的培育
- 批准号:
03558010 - 财政年份:1991
- 资助金额:
$ 20.61万 - 项目类别:
Grant-in-Aid for Developmental Scientific Research (B)
Developemtnt, Prfuction, and promotion of usilization of Mast Cell Deficient W/W/^v and Sl/Sl^d Mice.
肥大细胞缺陷型 W/W/^v 和 Sl/Sl^d 小鼠的发育、生产和利用促进。
- 批准号:
60880010 - 财政年份:1985
- 资助金额:
$ 20.61万 - 项目类别:
Grant-in-Aid for Developmental Scientific Research
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