Studies on the evaluation of photo allergic skin lesions from pesticides

农药光过敏性皮损评价研究

• 批准号: 02670225
• 负责人: MATSUSHITA Toshio
• 金额: $ 1.41万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02670225/
• 关键词: Pesticide; Photo sensitivity; Skin allergy; laser-Doppler; PNCB; Chlorothalonil; Paraquat; DDVP

In order to evaluate photo allergic skin lesions from pesticides, case analyses and experimental studies were undertaken. The results were as follows :1. From case analyses of skin lesions from pesticides : In cases of skin lesions from pesticides collected by reporting system, the incidence rates suspected to be photo allergy were relatively lower, i. e., about 2% in total number. The causative pesticides were various, and organophosphorus insecticides and sulfur fungicides were relatively dominant. But, the cases diagnosed definitely as photo allergic contact dernatitis were only small in number.2. From experimental studies on the skin lesions of photo allergy from pesticides :(1)Evaluation of the reaction using laser-Doppler flowmetry(LDF)method ; Comparative studies on the evaluation between the LDF method and the reading with the naked eyes were undertaken using guinea pigs and pesticides as captain, PNCB and zineb as a experimental model. From the method, different from the naked … More evaluation, high and low dose groups with PNCB irradiated to ultraviolet showed significantly high reaction at 24 and 48 hrs evaluation in its flow volume, and also in captain high dose group at 24 hr evaluation. The cross reactions among some pesticides were also estimated from the method, and it was suspected that this method is useful to evaluate photo sensitivity. But, from the method, it was difficult to distinguish between negative reaction and pseudopositive reaction estimated by the reading of the naked eyes.(2)Evaluation of photo sensitivity from pesticides by the Strip-Adjuvant technique ; am pesticides as zineb, captain, PNCB, DDVP, chlorothalonil, paraquat, etc. selected by our past experience and many references were studied to evaluate their photo sensitivity. Among those pesticides, chlorothalonil showed moderate to high potency of photo allergic reaction, and PNCB and paraquat also showed mild potency of photo allergic reaction. But, in case of DDVP, there were some discrepancies in reading on their experimental results. From the results, it was concluded that LDF method is useful to evaluate photo allergic skin lesions and some pesticides were also estimated to have a potency to cause photo sensitivity. Less

为了评价农药引起的光敏性皮肤损害，进行了病例分析和实验研究。1.农药皮损病例分析：在上报系统收集的农药皮损中，疑似光过敏的发病率相对较低，约占总数的2%。致病农药种类繁多，以有机磷杀虫剂和硫磺杀菌剂为主。但是，确诊为光敏性接触性皮炎的病例数量很少。农药光敏皮肤损伤的实验研究：(1)激光多普勒血流计(LDF)法评价反应以豚鼠和农药为队长，PNCB和Zineb为实验模型，用激光多普勒血流仪(LDF)法与肉眼读数进行比较研究。从方法上讲，不同于裸…进一步评价，紫外线照射PNCB的高剂量组和低剂量组在24小时和48小时的流量评价中有显著的高反应，船长高剂量组在24小时的评价中也有明显的高反应。并用该方法估算了几种农药间的交叉反应，推测该方法可用于光敏性评价。但从肉眼读数判断阴性反应和假阳性反应很难区分。(2)条状佐剂技术评价农药的光敏性。根据以往的经验，我们选择了代森锌、敌敌畏、百菌清、百草枯等AM类农药，并查阅了大量文献进行了光敏性评价。在这些农药中，百菌清表现出中到高度的光过敏反应，PNCB和百草枯也表现出轻微的光过敏反应。但是，在敌敌畏的情况下，他们的实验结果存在一些差异。结果表明，LDF法可用于光敏性皮肤损伤的评估，一些农药也可能具有引起光敏的效力。较少

项目成果

松下 敏夫他: "農薬による光アレルギ-性皮膚障害の検討" 産業医学. 33. 728 (1991)

Toshio Matsushita 等人：“农药引起的光过敏性皮肤病的研究”职业医学 33. 728 (1991)。

MATSUSHITA T.: "Photo contact sensitivitiy from pesticides" Contact Dermatitis. (1992)

MATSUSHITA T.：“农药的光接触敏感性”接触性皮炎。