Japan-China cooperative study on immuno-allergic disorders -Specially on the occurrence and treative measures-

中日免疫过敏性疾病合作研究-特别是其发生和治疗措施-

• 批准号: 07045054
• 负责人: MATSUSHITA Toshio
• 金额: $ 3.46万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07045054/
• 关键词: Immunologic disorders; Allergy; RA; epidemiology; Cooperative study; 慢性関節リウマチ; 皮膚免疫疾患; 職業アレルギー; 免疫学; アレルギー学; 接着分子; サイトカイン; 慢性リウマチ; アレルギー皮膚疾患; 表面抗原; HLA; 臨床疫学; 比較研究

In this cooperative investigation, the researchers in Kagashima University and China Medical University have been mainly engaged in the following themes : immunological mechanisms involved in chronic rheumatoid arthrutis, immune genetics on skin diseases, clinical epidemiology of contact dermatitis, evaluation of occupational sensitizers using cytokine profile analysis. During the period of 1995 to 1997, ten scientific researches in Kagoshima University have visited China Medical University for the cooperative study and scientific exchanges while fours Professors from China Medical University have also visited Kagoshima University shortly for these purposes. Further, in cooperared with China Medical University and other scientific organizations International Symposium on Occupational, Environmental Allergy and Immune Diseases was held in Shenyang during September 17-19,1997. The research works in this cooperative study were presented in the symposium and have received much attention.Th … More e main findings obtained in this cooperative study were as follows. (1) It has been demonstrated that soluble CD14, soluble VCAM-I and P-selection play important roles in the pathogensis of chronic rheumatoid arthritis. (2) In Chinese population, the prevalence of immune skin diseases have been found to associate with high frequence of HLA antigen expression. As evidence, anaphylactoid purpura was related wath high frequence of HLA-A30-31, B13, B35, B40 and DR10 while chronic urticaria was associated with high frequence of HLA-A,B,B44(12), DR2, DR7 and DQ2. (3) high prevalence of occupational dermatitis was observed among the workers in a aluminum smelting plant. The dermatitis frequence increased with ageing and increasing employing years. It was also found that personal allergic history, family allergic history, smoking and drinking habits acted as accelerating factors for occupational dermatitis. (4) The detection of cytokine mRNAs such as IL-2, IL-4, IL-12 and IFN-gamma would be useful for evaluating sensitizing potentials of occupational chemicals. Less

在本次合作研究中，鹿岛大学和中国医科大学的研究人员主要从事以下主题：慢性类风湿关节炎的免疫机制，皮肤病的免疫遗传学，接触性皮炎的临床流行病学，使用细胞因子谱分析评估职业致敏物。1995年至1997年，鹿儿岛大学的10名科研人员访问了中国医科大学进行合作研究和科学交流，中国医科大学的4名教授也访问了鹿儿岛大学。1997年9月17 ~ 19日，我院与中国医科大学等科研单位合作，在沈阳召开了职业、环境变态反应与免疫性疾病国际研讨会。本次合作研究的研究成果在研讨会上作了介绍，受到了广泛的关注。 ...更多信息 本合作研究的主要结果如下。(1)研究表明，可溶性CD 14、可溶性VCAM-1和P-选择素在慢性类风湿关节炎的发病中起重要作用。(2)在中国人群中，免疫性皮肤病的发生与HLA抗原的高表达有关。提示过敏性紫癜与HLA-A 30 -31、B13、B35、B40和DR 10的高频率相关，而慢性荨麻疹与HLA-A、B、B44（12）、DR 2、DR 7和DQ 2的高频率相关。(3)某铝冶炼厂工人职业性皮炎患病率较高。皮炎的发生率随着年龄的增长和工龄的增加而增加。个人过敏史、家族过敏史、吸烟、饮酒习惯是职业性皮炎的促发因素。(4)IL-2、IL-4、IL-12和IFN-γ等细胞因子mRNA的检测有助于评价职业化学品的致敏潜力。少

项目成果

〓 秀萍 等: "北方〓族〓敏性紫〓与HLA相〓性研究" 中〓医学〓〓学〓志. 14・2. 79-81 (1997)

〓 秀平等：“北方部落、敏感紫罗兰和HLA阶段的研究”《中华医学科学杂志》14・2（1997）。

Xu BH et al: "RT-PCR analysis of in vivo cytokine profiles in murine allergic contact dermatitis to DNCB" Toxicol Methods. 6(1). 23-31 (1996)

Xu BH 等人：“对 DNCB 过敏性接触性皮炎小鼠体内细胞因子谱进行 RT-PCR 分析”Toxicol 方法。

Kanzaki T et al: "Topical 5-fluorouragcil ointment for senile comedones" J Dermatol. 22. 376-377 (1995)

Kanzaki T 等人：“治疗老年粉刺的局部 5-氟尿嘧啶软膏”J Dermatol。

Kitani A et al: "T cells bound by vascular cell adhesion molecule-1/CD106 in synovial fluid in rheumatoid arthritis" J Immunol. (in press). (1996)

Kitani A 等人：“类风湿性关节炎滑液中的 T 细胞被血管细胞粘附分子-1/CD106 结合”，《免疫学杂志》。

Yao ZY et al: "Effect of Bifidobacterium Breve on Mouse Cellular Immunity" Chinese Journal of Microecology. 10・1. 1-5 (1998)

姚ZY等：“短双歧杆菌对小鼠细胞免疫的影响”中国微生态学杂志10・1（1998）。