Synthetic studies on evaluation of chronic toxicities from pesticides

农药慢性毒性评价综合研究

• 批准号: 04304034
• 负责人: MATSUSHITA Toshio
• 金额: $ 2.56万
• 依托单位: KAGOSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Co-operative Research (A)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04304034/
• 关键词: Pesticide; Chronic toxicity; Delayd neurotoxicity; Inhalation toxicity; Choronic poisoning; Chronic disorder; Skin lesion; Epidermiological survey; 有機燐殺虫剤

Significant findings were obtained by Studies on evaluation of chronic toxicities and the health disturbance from pesticides. The results were summarized as follows :(1)Evaluation for exposure levels to pesticides : A method was developed to estimate the exposure levels to pesticides by measuring the amount of pesticides adhered to the surfaces on the bodies in individuals during spraying. The utility of the method was evaluated(Yoshida). (2)Evaluation for chronic toxicities in animal experiments : References related to the values of animal experiments for the evaluation of chronic toxicities of pesticides were reviewed and especially, its technological aspects of the test methods in evaluation of toxicity were discussed (Tobe). (3)Evaluation for inhalation toxicities of pesticides : The toxicities of Inhaled acephate were investigated in animals, and an available index for the chronic toxicity of acephate was evaluated (Ando). (4)Experimental evaluation for chronic toxicities of organ … More ophosphates : A Japanese quails model to evaluate delaved neurotoxicity of organophosphates was established instead of hens. It was clarified that much stronger delayd neurotoxicity was developed by subcutaneous administration of the chemical than oral route (Kinebuchi). (5)Evaluation for skin lesions : Clinical cases of chronic skin lesions from pesticides were analyzed. Furthermore, patch tests with pesticides were carried out among agricultural workers and non-exposed persons to clarify the background factors of skin sensitization to pesticides (Matsushita). (6)Clinical evaluation for chronic toxicities of pesticides : Clinical cases diagnosed as chronic poisoning or chronic disorders from pesticides were collected and analyzed in the items of pesticides used, symptoms, findings from clinical examination, and so forth. On the basis of the research, a draft of the items for clinical questionnaire ad examinations was proposed for the health survey of agricultural workers (Matsushima). (7)Epidermiological evaluation for chronic toxicities of pesticides : By reviewing references related to the epidermiological study on health disturbance from pesti Less

农药的慢性毒性评价和健康危害研究取得了重要成果。（1）农药暴露水平的评估：建立了一种通过测量农药喷洒过程中个体体表农药附着量来评估农药暴露水平的方法。评价了该方法的实用性（Yoshida）。（2）动物实验中的慢性毒性评价：综述了与农药慢性毒性评价的动物实验价值有关的文献，特别讨论了毒性评价中试验方法的技术问题（Tobe）。（3）农药的吸入毒性评价：研究了乙酰甲胺磷的动物吸入毒性，并评价了乙酰甲胺磷慢性毒性的可用指标（Ando）。（4）慢性器官毒性实验评价 ...更多信息 磷酸盐：建立了一个日本鹌鹑模型来评价有机磷酸盐的神经毒性。澄清了皮下给予化学品比经口途径（Kinebuchi）产生更强的迟发性神经毒性。（5）皮损评价：对农药所致慢性皮损的临床病例进行分析。此外，在农业工人和非接触者中进行了农药斑贴试验，以澄清皮肤对农药致敏的背景因素（松下）。（6）农药慢性毒性的临床评价：收集临床诊断为农药慢性中毒或慢性疾病的病例，从所用农药、症状、临床检查结果等方面进行分析。在此基础上，提出了松岛县农业工人健康调查的临床问卷和检查项目草案。（7）农药慢性毒性的表皮学评价：通过对国内外有关农药致健康障碍的表皮学研究文献的回顾，总结了农药慢性毒性的研究进展。

项目成果

吉田政雄、他: "農薬散布におけるリエントリ-時の農作業者の安全性実態調査研究 第2報" 日本農村医学会雑誌. 41. 526-527 (1992)

Masao Yoshida 等人：“农药喷洒的重新进入 - 农场工人安全调查研究，第二次报告”日本农村医学会杂志 41. 526-527 (1992)。

H.Kinebuchi,et al.: "Hypocalcemia in delayed neuropathy caused by organophosphates" Environmental Sciences. 1. 199-204 (1992)

H.Kinebuchi 等人：“有机磷酸酯引起的迟发性神经病中的低钙血症”环境科学。

S.Tanaka,et al: "Combined repeat dose and reproductive/Developmental toxicity screening test(OECD):Familiarization using cyclophosphamide" Fundamental and Applied Toxicology. 18. 82-95 (1992)

S.Tanaka 等人：“组合重复剂量和生殖/发育毒性筛选试验（OECD）：熟悉环磷酰胺”基础和应用毒理学。

K.KUWAHARA: "Exposure to pesticide in greenhouses" J Jpn Assoc Rral Med.41(4). 970-974 (1992)

K.KUWAHARA：“温室中农药的暴露”Jpn Assoc Rral Med.41(4)。

FUJITA: "Nutritional intakes of farmers in tochigi" Jpn J Hyg. 48(1). 435 (1993)

藤田：“栃木县农民的营养摄入量”Jpn J Hyg。