Significance of endotoxemia and related cytokines in patients with liver disease

肝病患者内毒素血症及相关细胞因子的意义

• 批准号: 02670317
• 负责人: FUKUI Hiroshi
• 金额: $ 1.41万
• 依托单位: Nara Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02670317/
• 关键词: Endotoxin; Cytokines; Liver cirrhosis; Acute phase reactants; Albumin; Alcohol; インタ-ロイキン1; TNF; インタ-ロイキン6; 抗リピッドA

1) High levels of endotoxin (Et) was detected in the precipitate of HC10_4 treated plasma from severe cirrhotics. Plasma Et was increased in cirrhotics after rupture from esophageal varices. Serum levels of various acute phase proteins were positively correlated to Et Levels.2) In cirrhotics, Et binding capacity of albumin was significantly lower and those of HDL and transferrin were significantly higher than those in healthy subjects. Plasma Et binding capacity of albumin and Et inactivating rate was decreased in patients with severe cirrhosis. Et inactivating rate was positively correlated to serum HDL-cholesterol level and Et binding capacity of albumin. In the assay system albumin inhibited Et activity.3) Plasma IL-1beta, IL-6 and TNF were elevated in cirrhotics with terminal hepatic coma, in those with high plasma Et levels or in those with low Et binding capacity of albumin.4) In rat treated with alcohol Et clearance was prolonged and plasma TNF was elevated.

1)重度肝硬化患者经HC10_4处理后血浆沉淀物中高水平内毒素（Et）。食管静脉曲张破裂后肝硬化患者血浆Et升高。肝硬化患者血清各急性期蛋白水平与Et水平呈正相关。2)肝硬化患者白蛋白Et结合能力显著低于健康人，HDL和转铁蛋白Et结合能力显著高于健康人。重度肝硬化患者血浆Et结合能力和Et失活率下降。Et失活率与血清hdl -胆固醇水平和白蛋白Et结合能力呈正相关。在实验系统中，白蛋白抑制Et活性。3)肝硬化伴终末期肝昏迷者、血浆Et水平高者、血浆Et结合白蛋白能力低者血浆il -1 β、IL-6、TNF升高。4)经酒精处理的大鼠Et清除时间延长，血浆TNF升高。

项目成果

H. Fukui et al: "Plasma endotoxin inactivating mechanism in patients with liver cirrhosis : role of albumin" Proceedings of VIIth Meetings of Kinki Association for the Study of the Liver. (1992)

H. Fukui等：“肝硬化患者的血浆内毒素灭活机制：白蛋白的作用”近畿肝脏研究协会第七次会议论文集。

H.Fukui et al: "Plasma endotoxin concentration in patients with alcoholic and nonーalcoholic liver disease:reevaluation with an improved chromogenic assay" J Hepatology. 12. 162-169 (1991)

H.Fukui 等人：“酒精性和非酒精性肝病患者的血浆内毒素浓度：用改进的显色测定进行重新评估”J Hepatology 12. 162-169 (1991)。

H.Fukui,et al: "Plasma endotoxin concentration in patients with alcoholic and nonーalcoholic liver disease:reevaluation with an improved chromogenic assay" J Hepatology. 12. 162-169 (1991)

H.Fukui 等人：“酒精性和非酒精性肝病患者的血浆内毒素浓度：用改进的显色测定进行重新评估”J Hepatology，12. 162-169 (1991)。

福井 博ほか: "肝硬変における血中エンドトキシン不活性化機構ーアルブミンの関与を中心に" 第7回近畿肝臓病研究会論文集.

Hiroshi Fukui等：“肝硬化中的血液内毒素灭活机制——聚焦于白蛋白的参与”第七届近畿肝病研究组论文集。

H.Fukui et al: "Plasma endotoxin concentration in patients with alcohlic and nonalcohlic liver desease:reevaluation with an improved chromogenic assay" J Hepatology. 12. 162-169 (1991)

H.Fukui 等人：“酒精性和非酒精性肝病患者的血浆内毒素浓度：使用改进的显色测定进行重新评估”J Hepatology。