心筋脂肪酸摂取率による心筋虚血の早期検出及び大きさの判定に関する研究

基于心肌脂肪酸摄取率的心肌缺血早期检测及大小判断研究

• 批准号: 02670388
• 负责人: 横田 充弘
• 金额: $ 1.09万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02670388/
• 关键词: 運動誘発心筋虚血; 血中遊離脂肪酸; 心筋脂肪酸摂取率; 脂肪酸構成

本研究では,HPLCによる脂肪酸分析法に用い,I運動誘発心筋虚血の早期検出に血中遊離脂肪酸の測定が有用であるか否か,2.心筋虚血時に血中遊離脂肪酸構成に変化が見られるか否かについて検討した。安定労作狭心症患者8例を対象としてコントロ-ルでは中等度狭心痛を運動終点に,nilvadipine投与後にはコントロ-ルと同一運動時間を運動終点とする多段階臥位自転車エルゴメ-タ運動試験を施行し、以下の成績を得た。1.心筋脂肪酸摂取率は安静時21.1±4.4%に比し最大運動時8.1±2.1%と有意に低下した(p〈0.05)。2.動脈および冠静脈洞血中の脂肪酸構成は虚血により有意な変化を示さなかった。3.心筋乳酸摂取率は安静時21.6±2.7%,最大運動時22.2±3.3%と有意な変化を示さなかった。4.Nilvadipine投与により胸痛発作の消失ないし軽減,虚血性ST下降の有意な軽減を認めた。5.Nilvadipine投与後の心筋脂肪酸摂取率は安静時25.3±2.7%,最大運動時21.3±3.6%と有意な変化を示さなかった。以上より,心筋脂肪酸摂取率は心筋乳酸摂取率に比して早期の運動誘発心筋虚血の指標となりうると思われる。

In this study, the method of HPLC fatty acid analysis was used to determine the content of isolated fatty acids in blood in the early stage of heart muscle deficiency. 2. When the heart muscle is deficient and the blood is deficient, the isolated fatty acids in the blood will not be affected by the formation of fatty acids. Eight patients with narrow heart disease were treated with diazepam. In 8 patients with narrow heart disease, diazepam was used in 8 patients with narrow heart disease. in 8 patients with narrow heart disease, diazepam was used in 8 patients with narrow heart disease. in 8 patients with narrow heart disease, diazepam was used in 8 patients with narrow heart disease, and the following results were successful. 1. The heart fatty acid intake rate of 21.1 ±4.4% at rest was intentionally lower than that of 8.1 ±2.1% at maximum exercise (p < 0.05). two。 The fatty acid in the blood of the coronary stillness hole is formed into deficiency blood and indicates that it is intentionally changed. 3. The recovery rate of cardiac lactic acid is 21.6 ±2.7% at rest, and the maximum exercise time is 22.2 ±3.3%. When 4.Nilvadipine was used to treat chest pain, the blood-deficiency ST decreased intentionally, and chest pain disappeared. The recovery rate of heart fatty acids after 5.Nilvadipine injection was 25.3 ±2.7% at rest, and the maximum exercise time was 21.3 ±3.6%. The recovery rate of heart muscle fatty acid and lactic acid was higher than that of early exercise, heart muscle deficiency and blood deficiency.

项目成果

Makoto Watanabe: "Clinical Significance of Simple Heart RateーAdjusted ST Segment Depression in Supine Leg Exercise in The Diagnosis of Coronary Artery Disease" American Heart Journal. 120. 1102-1110 (1990)

Makoto Watanabe：“仰卧腿部运动中简单心率调整 ST 段压低在诊断冠状动脉疾病中的临床意义”《美国心脏杂志》120。1102-1110 (1990)。