Usefulness of a skeletal muscle pump for improvement of cardiac function long term after Fontan's operation

骨骼肌泵在 Fontan 手术后长期改善心功能的作用

• 批准号: 02670603
• 负责人: HIROSE Hajime
• 金额: $ 1.54万
• 依托单位: Gifu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02670603/
• 关键词: Skeletal muscle pump; Artificial heart; Fonton犬; 骨格筋トレ-ニング

To investigate usefulness of skeletal muscle as cardiomyplasty for cardiac assist after Fontan's operation, we have done Fontan's operation on mongrel dogs with simple hypothermia method, but in vein. So, we use some cardiac assist device such as IABP, after Fontan's operation, but, no dogs survived. Thereafter, we have changed the purpose of this research.So, we have evaluated skeletal muscle performance of latissimus dorsi muscle actuator for an artificial heart.Advantage of this system are: 1)the muscle power was linearly transmitted effectively, 2)this system could be installed with minimal surgery and without interruption in blood flow to the muscle, 3)the muscle is free from high intraventricular pressure that caused ischemia and,4) the muscle can be set to the proper length in diastole to potentiate strong contractions.Using mongrel dogs, the latissimus dorsi muscle was dissected at the lower ribs, and its end was connected with the flexible rod. The contraction of skeletal muscle was linearly transmitted, with the rod introduced inside the sheath, to the artificial heart. In these experiments, the pump output was maintained at 0.8 to 2.01/min (60bpm) for 200min, with non-preconditioned muscle that was stimulated continuously. The output obtained was 2.5mW/gram.This result was presented on ASAIO(1992, May, Nashville, Tennessee. USA)

为探讨骨骼肌移植在Fontan手术后心脏辅助手术中的应用价值，我们用简单的低温方法对杂种犬进行了Fontan手术，但在静脉中。因此，我们在Fontan手术后使用了一些心脏辅助装置，如IABP，但没有狗存活。因此，我们改变了本研究的目的。因此，我们评估了用于人工心脏的背阔肌驱动器的骨骼肌性能。该系统的优点是：1）肌肉力量被有效地线性传输，2）该系统可以用最少的手术安装，并且不会中断流向肌肉的血流，3）肌肉没有引起局部缺血的高心室内压，（4）背阔肌可在胸壁内固定，以增强肌的收缩力。用杂种犬，在肋骨下段解剖背阔肌，将其末端与弹性棒连接。骨骼肌的收缩是线性传输的，与杆引入鞘内，人工心脏。在这些实验中，泵输出保持在0.8至2.01/min（60 bpm）持续200 min，其中连续刺激非预处理的肌肉。获得的输出功率为2.5mW/g，该结果在ASAIO（1992年5月，纳什维尔，田纳西州）上发表。美国）

项目成果

Eisaku Sasaki: "A Skeletal Muscle Actuator for an Artificial Heart." Asaio Transactions. 38. 507-511 (1992)

佐佐木荣作（Eisaku Sasaki）：“用于人造心脏的骨骼肌致动器。”

E Sasaki, H Hajime, S Murakawa, Y Mori, T Yamada H Itoh, M Ishikawa, S Senga, S Sakai, Y Katagiri, M Hashimoto, S Fuwa, and K Azuma: "A Skeletal Muscle Actuator for an Artificial Heart." Asaio Transactions. 38(3). (1992)

E Sasaki、H Hajime、S Murakawa、Y Mori、T Yamada H Itoh、M Ishikawa、S Senga、S Sakai、Y Katagiri、M Hashimoto、S Fuwa 和 K Azuma：“用于人工心脏的骨骼肌致动器。”