Usefulness of a skeletal muscle pump for improvement of cardiac function long term after Fontan's operation

为探讨Fontan‘s手术后应用骨骼肌作为心脏辅助的心肌成形术的有效性，我们用简单的低温方法对杂种犬进行了Fontan’s手术。因此，在Fontan的手术后，我们使用了一些心脏辅助装置，如IABP，但没有狗存活。因此，我们评估了人工心脏背阔肌执行器的骨骼肌性能。该系统的优点是：1)肌肉能量线性有效地传递，2)该系统可以安装在最小手术且不中断肌肉的血流的情况下，3)肌肉不受引起缺血的高脑室内压的影响，4)肌肉可以在舒张期设定适当的长度以增强强烈的收缩。使用杂种狗，背阔肌在肋骨下部分离，其末端与柔性杆相连。骨骼肌的收缩随着杆子被引入鞘内而线性地传递到人工心脏。在这些实验中，泵的输出量保持在0.8到2.01次/分钟(60bpm)，持续刺激未预适应的肌肉200min。获得的输出功率为2.5 mW/g。这一结果在ASAIO(1992年5月，田纳西州纳什维尔)上公布。美国)

To investigate usefulness of skeletal muscle as cardiomyplasty for cardiac assist after Fontan's operation, we have done Fontan's operation on mongrel dogs with simple hypothermia method, but in vein. So, we use some cardiac assist device such as IABP, after Fontan's operation, but, no dogs survived. Thereafter, we have changed the purpose of this research.So, we have evaluated skeletal muscle performance of latissimus dorsi muscle actuator for an artificial heart.Advantage of this system are: 1)the muscle power was linearly transmitted effectively, 2)this system could be installed with minimal surgery and without interruption in blood flow to the muscle, 3)the muscle is free from high intraventricular pressure that caused ischemia and,4) the muscle can be set to the proper length in diastole to potentiate strong contractions.Using mongrel dogs, the latissimus dorsi muscle was dissected at the lower ribs, and its end was connected with the flexible rod. The contraction of skeletal muscle was linearly transmitted, with the rod introduced inside the sheath, to the artificial heart. In these experiments, the pump output was maintained at 0.8 to 2.01/min (60bpm) for 200min, with non-preconditioned muscle that was stimulated continuously. The output obtained was 2.5mW/gram.This result was presented on ASAIO(1992, May, Nashville, Tennessee. USA)