The heterogeneity of various Porphyromonas gingivalis strains to adherence and invasive.

各种牙龈卟啉单胞菌菌株粘附和侵袭的异质性。

• 批准号: 02670816
• 负责人: NAITO Yuko
• 金额: $ 1.41万
• 依托单位: Tokyo Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02670816/
• 关键词: Porphyromonas gingivalis; fimbriae; hydrophobicity; vesicle; collagen; vosicle

Porphyromonas gingivalis has been associated with adult periodontitis in human. The organism has been shown to attach to collagen which is major component gingival tissue. Moreover, we found that there were clear heterogeneity among P. gingivalis strains in their attachment to collagen coated HA. Avirulence strains adherent to oral tissue much than virulence strains in gigival sulcus. We have also clarified that an overall corelation was noted between the adsorption of strains P. gingivalis to hexadecane and their numbers which attached to collage formed on hydroxyapatite surfaces. Our study has proved the evidence that the difference in hydrophobic properties of strains may be due to difference of fimbriae which has appeared to be capable of attachment to collagen coated HA. On the other hand, vesicles have the adhesion which were adherent to pellicle or collagen coated hydropxyapatite regardless of virulence.

牙龈牙龈牙龈药与人类的成年牙周炎有关。该生物体已显示与主要成分牙龈组织附着在胶原蛋白上。此外，我们发现牙龈牙龈疟原虫菌株之间存在明显的异质性。依靠口腔组织的气相菌株比在千古沟中的毒力菌株要多得多。我们还澄清说，牙龈或齿轮菌对十六进制的吸附及其数量附着在羟基磷灰石表面上的拼贴物之间。我们的研究证明了菌株疏水性质的差异可能是由于脂肪差异差异，这似乎已经能够附着在胶原蛋白涂层的HA上。另一方面，无论毒力如何

项目成果

Y.Naito,K.Okuda,I.Takazoe: "Comparatiwe hydrophobicity of various Porphyroーmonas gingivalis strains and their adherence to collagen substrate"

Y.Naito、K.Okuda、I.Takazoe：“不同牙龈卟啉单胞菌菌株的疏水性比较及其对胶原基质的粘附”

Y. Naito: Analysis of adherence mechanizum of periodontal bacteria. Shikwa gakuhou, 92 (1992)

Y. Naito：牙周细菌粘附机制的分析。

内藤 祐子: "歯周病原菌の付着機序についての解析" 歯科学報. 92. (1992)

内藤裕子：“牙周病原菌的粘附机制分析”牙科杂志92。（1992）

K. Ishihara, Y. Naito, et al: "A sensitive enzymatic method (SK-013) for detection and quantification of specific periodontopathogens" J Periodont Res. 26. (1992)

K. Ishihara、Y. Naito 等人：“用于检测和定量特定牙周病原体的灵敏酶法 (SK-013)”J periodont Res。

内藤 祐子: "歯肉溝液の免疫物質" 歯科ジャ-ナル. 31. 729-738 (1990)

Yuko Naito：“龈沟液中的免疫物质”《牙科杂志》31. 729-738 (1990)。