Elucidation of regulatory mechanism of B cell activation by the change in sialic acid species

我曾报道过，在生发中心激活的B细胞中，主要的唾液酸种类发生了巨大的变化，其形成是由胸腺依赖（TD）抗原免疫引发的。在这个项目中，我建立了有望消除唾液酸物种激活依赖性变化的转基因小鼠，并分析了这些小鼠的B细胞表型。由于这些小鼠在TD抗原免疫后形成生发中心，我检查了TD反应中的抗体产生。

I have reported that major sialic acid species is dramatically changed in activated B cells in germinal centers, the formation of which is triggered by immunization with thymus-dependent (TD) antigen. In this project, I established genetically modified mice that were expected to cancel the activation-dependent change in sialic acid species, and analyzed B cell phenotypes of these mice. Since these mice formed germinal centers upon TD antigen immunization, I examined antibody production in TD response.