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SALIVARY CHROMOGRANIN A AND S-IgA AS PSYCHOSOMATIC AND PHYSICAL STRESS MARKER

唾液嗜铬蛋白 A 和 S-IgA 作为心身和身体压力标记

基本信息

批准号：
11680050
负责人：
NAITO Yuko
金额：
$ 2.37万
依托单位：
KOKUSHIKAN UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11680050/
关键词：
saliva Chromogranin A sIgA stress psychosomatic stressor BMD stress marker bone mineral calcium

项目摘要

The effect of psychological stress and physical stress on salivary chromogranin A and salivary immunoglobulin A (sIgA) concentrations was studied in University athletes. A total of 12 males (19.1±1.1years old), who completed the continuous high-intensity running between 6 days as physical stress and the 20km half-marathon race as psychosomatic stress, were studied. Saliva samples were collected one day before and after the hard training, also were done 2 days before and one day after the race, to measure the levels of salivary chromogranin A and sIgA.At the same time, each subject completed a profile of mood state questionnaire (POMS), designed the measure six mood factors ; tension, depression, anger, vigor, fatigue, and confusion.The results are summarized as follows. 1. The concentration of salivary chromogranin A indicated a low level two days before the race and increased one day after the race. 2. A strong negative correlation was observed between the change in concentration of salivary chromogranin A and the vigor score one day after the race (p<0.05). On the other hand, the level of salivary chromogranin A showed no change before and after hard training as physical stress. 3. A strong positive correlation was observed between the change in concentration of salivary sIgA and the vigor score after the hard training (p<0.05). 4. These results suggest that salivary chromogranin A elevated distinctively in response to not physical stressor but psychosomatic stressor and thus the level is considered to be a sensitive index for psychosomatic stressor.

研究了心理压力和身体压力对大学运动员唾液嗜铬粒蛋白 A 和唾液免疫球蛋白 A (sIgA) 浓度的影响。研究对象为12名男性（19.1±1.1岁），他们完成了6天连续高强度跑步作为身体应激，并完成了20公里半程马拉松作为心身应激。在艰苦训练前一天和后一天采集唾液样本，并在比赛前两天和比赛后一天采集唾液样本，测量唾液中嗜铬粒蛋白A和sIgA的水平。同时，每个受试者完成一份情绪状态问卷（POMS），设计了测量六种情绪因素；紧张、抑郁、愤怒、活力、疲劳、困惑。结果总结如下。 1. 唾液嗜铬粒蛋白A浓度在赛前两天呈低水平，赛后一天升高。 2.赛后一天唾液嗜铬粒蛋白A浓度变化与活力评分呈强负相关(p<0.05)。另一方面，在身体压力等艰苦训练前后，唾液嗜铬粒蛋白A的水平没有变化。 3.艰苦训练后唾液sIgA浓度变化与活力评分呈强正相关(p<0.05)。 4.这些结果表明，唾液嗜铬粒蛋白A的升高不是针对身体应激源，而是针对心身应激源，因此该水平被认为是心身应激源的敏感指标。