Sensory Processing mechanisms in periaqueductal gray matter.

导水管周围灰质的感觉处理机制。

• 批准号: 02670826
• 负责人: TODA Kazuo
• 金额: $ 1.66万
• 依托单位: Tokyo Medical and Dental University, Faculty of Dentistry.
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02670826/
• 关键词: periaqueductal gray matter; somatosensory area; noxious stimulation; wide dynamic range neuron; wind up; serotonin; morphine; rat; 大縫線核; 受容野; ワインドアップ

Characteristics of somatosensory inputs to the periaqueductal gray matter (PAG) neurons were investigated using barbiturate-anesthetized Wistar albino rats. Results were as follows :(1) there were at least 2 types of PAG neurons according to their receptive fields. One was large type (PAG-L), and the other was small type (PAG-S).(2) Both types of neurons were activated by nonoxious (touch/ heat) and noxious (mechanical, heat and chemical) stimulation.(3) In a majority of PAG-L type neurons, wind-up phenomenon was observed.(4) Microiontophoretically applied morphine onto the PAG-S type neurons increased their spontaneous activities.(5) The threshold value of noxious heat stimuli applied to the PAG-S type neurons was higher than that applied to the PAG-L type neurons.

用巴比妥酸麻醉的Wistar白化病大鼠研究了中脑导水管周围灰质（PAG）神经元的体感输入特性。结果表明：（1）PAG神经元按感受野至少有两种类型。一个是大型（PAG-L），另一个是小型（PAG-S）。(2)这两种类型的神经元激活nonoxious（触摸/热）和有害（机械，热和化学）刺激。(3)在大多数PAG-L型神经元中，观察到缠绕现象。(4)微电泳吗啡可增加PAG-S型神经元的自发活动。(5)对PAG-S型神经元的伤害性热刺激阈值高于PAG-L型神经元。

项目成果

TODA, Kazuo: "Responses of descending periaqueductal gray matter neurons to nonoxious and noxious mechanical stimuli in rats" Jpn. J. Physiol.40. s195 (1990)

TODA，Kazuo：“大鼠中导水管周围灰质下降神经元对无害和有害机械刺激的反应”Jpn。

TODA KAZUO: "Central mechanisms of acupuncture analgesia" J.Jap.Dent.Orient.Med.8. 3-13 (1990)

户田一雄：“针灸镇痛的中心机制”J.Jap.Dent.Orient.Med.8。

戸田 一雄: "下行性中脳水道周囲灰白質ニュ-ロンの侵害受容性応答に対するセロトニンの作用" 日本疼痛学会誌. 5. 111-111 (1990)

Kazuo Toda：“血清素对导水管周围灰色神经元伤害性反应的影响”日本疼痛学会杂志 5. 111-111 (1990)。

戸田 一雄: "針鎮痛発現の中枢メカニズム" 日本歯科東洋医学会雑誌. 8. 3-13 (1990)

Kazuo Toda：“针灸镇痛的中枢机制”日本牙科东方医学会杂志 8. 3-13 (1990)。

Sumino,R;Iwata,K;Toda,K.: "Microneurographical analysis of inferior dental nerue activities of human teeth." Pain. S5. 40-40 (1990)

Sumino,R;Iwata,K;Toda,K.：“人类牙齿下牙神经活动的显微神经学分析。”