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Role of cingulate cortex in modulating pain sensation

扣带皮层在调节痛觉中的作用

基本信息

批准号：
04671122
负责人：
TODA Kazuo
金额：
$ 1.28万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1992
资助国家：
日本
起止时间：
1992 至 1993
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04671122/
关键词：
Descending inhibition cingulate nociception serotonin PAG Rat ラット侵害刺激セロトニン

项目摘要

Extracellular recording was made from single cells in the anterior cingulate cortex (ACCX) which projected descendingly to the periaqueductal gray matter (PAG) in barbiturate-anesthetized rats. After mechanical stimulation (nonnoxious von Frey hair and noxious pinch), ACCX neuronms were devided into two types : one is wide dynamic range (WDR), and the other is noxious specific(NS) neurons. Almost all of these neurons were found in the layr V of the area 24. None of the low threshold mechanoreceptive neurons (LTM) neurons were found. Most units of the ACCX had broad receptive fields of the both sides, and those of the WDR neuron were significantly larger than those of the NS ones (Wilcoxon rank test, p<0.05). About a half of the WDR (46%) and a majority of the NS (89%) neurons excited to heat stimuli applied to their mechanical receptive fields. In the NS neurons, off-response was often observed after the cessation of heat stimulation. Threshold value of the heat stimuli for the WDR neuron was 44.5-2.7 C (nean-SD, n=6), and that for the NS one was 46.4-2.1 (n=17). These results show that all the descending ACCX neurons are nociceptive, at least receiving mechanical and heat noxious inputs, suggesting that the ACCX plays a significant role for processing noxious information using negative feedback circuits involving in the PAG system.

用巴比妥酸麻醉大鼠的前扣带皮层（ACCX）单细胞向下投射到导水管周围灰质（PAG）进行细胞外记录。经机械刺激（非毒性von Frey毛发和毒性捏捏）后，ACCX神经元分为两类：一类是宽动态范围（WDR）神经元，另一类是毒性特异性（NS）神经元。几乎所有这些神经元都位于24区的V层。低阈机械感受神经元（LTM）未见。大部分ACCX单元双侧感受野较宽，其中WDR神经元的感受野明显大于NS神经元（Wilcoxon秩检验，p<0.05）。大约一半的WDR神经元（46%）和大多数NS神经元（89%）对施加于其机械感受野的热刺激感到兴奋。在NS神经元中，热刺激停止后常出现无反应现象。WDR神经元的热刺激阈值为44.5 ~ 2.7 C (mean - sd, n=6)， NS神经元的热刺激阈值为46.4 ~ 2.1 C （n=17）。这些结果表明，所有下行的ACCX神经元都是伤害性的，至少接受机械和热有害的输入，这表明ACCX在处理有害信息方面发挥了重要作用，使用涉及PAG系统的负反馈回路。