Subtypes of Nociceptors in the Oral region.

口腔区域伤害感受器的亚型。

• 批准号: 10671735
• 负责人: TODA Kazuo
• 金额: $ 2.11万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671735/
• 关键词: nociceptor; polymodal; mechanoreceptor; gingiva; tooth pulp; periodontium; bitter; rat; スラジキニン; 苦味; フオンフライ

Properties of nociceptors of skin have been extensively investigated, however, less is known about the characteristics of nociceptive afferents that innervate mucosal areas. In the present review, recent studies of the nociceptors in the oral mucosa are summarized. Oral mucosal nociceptors has different properties from the skin nociceptors. This means quite important for detection of nociceptive stimulus which applied during daily food intake. In addition, some of the mucosal nociceptors were also excited by bitter solution, suggesting that these nociceptors in the oral mucosa play a significant role in production of taste sensation by irritant foods. Tooth pulpal and periodontal nociceptors were also investigated, showing that distributions of nociceptors are different among these structures.

皮肤痛觉感受器的特性已经被广泛研究，然而，对支配粘膜区域的痛觉传入的特性知之甚少。本文就近年来口腔粘膜损伤感受器的研究进展作一综述。口腔粘膜伤害感受器与皮肤伤害感受器具有不同的性质。这对于检测日常食物摄入过程中产生的伤害性刺激具有重要意义。此外，一些粘膜伤害感受器也被苦味溶液激发，这表明口腔粘膜的这些伤害感受器在刺激性食物产生味觉感觉中起着重要作用。牙髓和牙周的伤害感受器也被研究，表明这些结构中伤害感受器的分布是不同的。

项目成果

Toda K et al.: "Tooth pulpal nociceptors in the rat lower incisor"Pain Res.. 13・3. 57-63 (1998)

Toda K 等：“大鼠下切牙的牙髓伤害感受器”Pain Res.. 13・3 (1998)。

Toda, K. et al.: "Subtypes of oral mucosal nociceptors : an in vitro study in rats."Neurobiology of Mastication. Eds., Nakamura, Y., Sessle, B. J., (Elsevier, Amsterdam). 189-200 (1999)

Toda, K. 等人：“口腔粘膜伤害感受器的亚型：大鼠体外研究。”咀嚼神经生物学。

Toda, K. et al.: "Responses of oral mucosal nociceptors to bitter solutions in an in vitro rat jaw-nerve preparation."Jpn. J. Physiol.. 48. 412-412 (1998)

Toda, K. 等人：“口腔粘膜伤害感受器对体外大鼠颌神经制剂中苦味溶液的反应”。

Toda, K. et al.: "Tooth pulpal nociceptors in the rat lower incisor, An in vitro study."Pain Res. 13. 57-63 (1998)

Toda, K. 等人：“大鼠下切牙的牙髓伤害感受器，一项体外研究。”疼痛研究。

"Characteristics of rat oral mucosal nociceptors."Abstracts for 9th IASP. (1999)

“大鼠口腔粘膜伤害感受器的特征。”第九届 IASP 摘要。