Integrative mechanisms for protopathic sensation including pain and g ravitropism

原病感觉的整合机制,包括疼痛和向地性

基本信息

  • 批准号:
    18613011
  • 负责人:
  • 金额:
    $ 2.25万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2006
  • 资助国家:
    日本
  • 起止时间:
    2006 至 2007
  • 项目状态:
    已结题

项目摘要

Neuronal mechanisms of nociceptive and gravitational responses were investigated in c. elegans. Wild type c.eleganse was stimulated by noxious or high gravity stimulation. Noxious stimulations were maechanical (von Frey type apparatus), chemical, heat, pH and osmomic ones. Gravity stimulation was high- gravity of 1.2-2.0G. Main results were as follows: (1)Threshold values of mechanical stimulation for avoidance reflex showing escape from the stimulus site were lower than that evoked pain sensation in man. A typical behavior of avoidance reflex is peristalsis or coiling motion (2)Pain producing substances, such as Bradykinin, Histamine, 5-HT were not effective on the avoidance reflex in C. elegans. (3)Low pH and low osmomic stimulation were quite effective for evoking coiling reflex.Next, we investigated interaction between noxious and gravitational stimuli. For this purpose, nociceptive threshold before and after gravitational stimulation were compared. Centrifugal apparatus were used to apply high gravity. For 30 min. For mechanical threshold, it was higher after gravitational stimulation. Degree of threshold changes by gravitational simulation was dose-response fashon For example, 2G was more effective than 1.2 G stimulation on the von Frey-induced escape response. Chemical threshold to evoke nociceptive response were not changed even after gravitational stimulation. 2G stimulation enhanced low osmimic-induced escape behavior. The present results suggest that prtopathic sensation may be integrated in the central nervous system. Both nociceptive and gravitational sensations are critical for the preservation of the species in animals.
在c.优雅的野生型秀丽隐杆线虫受到伤害性或高重力刺激。伤害刺激是机械的(von Frey型装置),化学的,热的,pH值和渗透压的。重力刺激为1.2-2.0G的高重力。主要结果如下:(1)机械刺激引起的回避反射阈值低于人的痛觉阈值,回避反射的典型行为是痉挛或盘卷运动。(2)缓激肽、组胺、5-HT等致痛物质对豚鼠回避反射无明显影响。优美的(3)低pH和低渗透刺激对诱发卷曲反射有较好的效果。为此目的,比较重力刺激前后的伤害性阈值。离心装置用于施加高重力。对于机械阈值,重力刺激后更高。重力模拟的阈值变化程度呈剂量-反应关系。例如,2G比1.2G刺激对von Frey诱导的逃避反应更有效。诱发伤害性反应的化学阈值,即使在重力刺激后也没有改变。2G刺激增强低渗诱导的逃避行为。结果提示,前病变感觉可能与中枢神经系统有关。伤害感受和重力感觉对于动物物种的保存至关重要。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Splenius muscle activities induced by temporomandibular joint stimulation in rats.
大鼠颞下颌关节刺激诱导的夹肌活动。
  • DOI:
  • 发表时间:
    2007
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Kobayashi M;Yabushita T;Zeredo JL;Toda K;Soma K.
  • 通讯作者:
    Soma K.
Functional changes of the temporomandibular joint mehanoreceptors induced by a lateral mandibular shift in rats.
大鼠下颌侧移引起的颞下颌关节机械感受器的功能变化。
  • DOI:
  • 发表时间:
    2007
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Kokai S;Yabushita T;Zeredo JL;Toda K;Soma K
  • 通讯作者:
    Soma K
Characteristics of biphasic slow depolarizing and slow hyperpolarizing potential in frog taste cell induced by parasympathetic efferent stimulation.
  • DOI:
    10.1093/chemse/bjm049
  • 发表时间:
    2007-11
  • 期刊:
  • 影响因子:
    3.5
  • 作者:
    Toshihide Sato;K. Nishishita;Y. Okada;K. Toda
  • 通讯作者:
    Toshihide Sato;K. Nishishita;Y. Okada;K. Toda
Analysis of slow depolarizing potential in frog taste cell induced by parasympathetic efferent stimulation under hypoxia.
  • DOI:
    10.1093/chemse/bjm003
  • 发表时间:
    2007-05
  • 期刊:
  • 影响因子:
    3.5
  • 作者:
    Toshihide Sato;Kazushisa Nishishita;Y. Okada;K. Toda
  • 通讯作者:
    Toshihide Sato;Kazushisa Nishishita;Y. Okada;K. Toda
Fundamentals of Pain(book)
疼痛的基础知识(书籍)
  • DOI:
  • 发表时间:
    2007
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Ueda;H.;Toda;K
  • 通讯作者:
    K
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TODA Kazuo其他文献

TODA Kazuo的其他文献

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{{ truncateString('TODA Kazuo', 18)}}的其他基金

Sex differences in pain perception and plasticitical role of descending inhibitory system
疼痛感知的性别差异和下行抑制系统的可塑性作用
  • 批准号:
    24590727
  • 财政年份:
    2012
  • 资助金额:
    $ 2.25万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Modulation of nociceptive genes by in vivo RNA interference in rats and application to pain treatment
大鼠体内RNA干扰对伤害感受基因的调节及其在疼痛治疗中的应用
  • 批准号:
    21600006
  • 财政年份:
    2009
  • 资助金额:
    $ 2.25万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Functional Development of Nociceptors in the Oral Mucosa
口腔粘膜伤害感受器的功能发育
  • 批准号:
    12671800
  • 财政年份:
    2000
  • 资助金额:
    $ 2.25万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Subtypes of Nociceptors in the Oral region.
口腔区域伤害感受器的亚型。
  • 批准号:
    10671735
  • 财政年份:
    1998
  • 资助金额:
    $ 2.25万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Role of cingulate cortex in modulating pain sensation
扣带皮层在调节痛觉中的作用
  • 批准号:
    04671122
  • 财政年份:
    1992
  • 资助金额:
    $ 2.25万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
Sensory Processing mechanisms in periaqueductal gray matter.
导水管周围灰质的感觉处理机制。
  • 批准号:
    02670826
  • 财政年份:
    1990
  • 资助金额:
    $ 2.25万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
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