Modulation of nociceptive genes by in vivo RNA interference in rats and application to pain treatment

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Neuropathic pain can be very difficult to treat. It may be associated with abnormal sensations called dysesthesia, and pain is produced by normally non-noxious stimuli(allodynia). Recently, it is reported that nociceptive-genes are strongly concerned with producing neuropathic pain and inhibition of nocicptive-gene expression is one of the tools to treat neuropathic pain. This study revealed that inhibition of nocicptive-genes by in vivo RNA interference elevated threshold value to mechanical noxious stimuli.