权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Development of long term use menbrane oxygenator built-in artificial heart

长期使用膜式氧合器内置人工心脏的研制

基本信息

批准号：
03557058
负责人：
TAKANO Hisateru
金额：
$ 7.87万
依托单位：
National Cardiovascular Center Research Institute
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research (B)
财政年份：
1991
资助国家：
日本
起止时间：
1991 至 1993
项目状态：
已结题

项目摘要

As the heart and lung frequently fail simultaneously due to the extensive interaction of these closely related organs, it has been expected to develop such a device as to support these organs at the same time. On the basis of this back ground, we have developed a novel assist system for long-term cardiopulmonary support ; an integrated artificial heart-lung device (IAHLD). The IAHLD consists of a compact oxygenator and two pneumatic pusher-plate type artificial hearts. The oxygenator is made of two layred non-porous membrane hollow fibers in which an ultrathin dense layr formed at the blood contacting surface prevents serum leakage. The fibers are potted in a cylindrical polyurethane potting (phi60 mm X 70 mm) which also serves as a housing. The artificial heart has an inlet (or outlet) port with a Bjork-Shiley valve and a coupler of 60 mm in diameter. The artificial heart are coupled to each and of the oxygenator with the coupler ; thus all components are incorporated. With this special structure, we intended to avoid low flow areas, which causes thrombus formation and gas exchange deterioration. The gas transfer performance of the prototype device (gas exchange area =1.5m^2, priming volume = 400 ml) was 300 ml/min for oxygen and 250 ml/min for carbon dioxide at a blood flow rate of 5 L/min. Venoarterial bypass using the prototype device could satisfactory replace the total cardiopulmonary function in a nonfunctioning heart-lung model of a goat weighing 60 kg. During 6 hours of pumping, hemodynamic parameters of the goat was maintained fairly stable and blood gas data was kept above 300 mmHg for PaO_2 and below 30 mmHg for PaCO_2. We are also developing a technique for thromboresistant surface treatment : covalent heparin bonding technique. Although this research is still premature, we believe that we can make it practical in a near future.

由于这些密切相关的器官之间的广泛相互作用，心脏和肺经常同时衰竭，因此人们一直期望开发这样一种装置来同时支持这些器官。在此背景下，我们开发了一种新型的长期心肺支持辅助系统；集成人工心肺装置（IAHLD）。IAHLD由一个紧凑型氧合器和两个气动推板式人工心脏组成。氧合器由两层无孔膜中空纤维制成，其中在血液接触面形成超薄致密层，防止血清泄漏。纤维被装入圆柱形聚氨酯容器（phi60 mm X 70 mm）中，该容器也用作外壳。人工心脏有一个入口（或出口）口，有一个比约克-希利阀和一个直径60毫米的耦合器。所述人工心脏通过所述耦合器与所述氧合器耦合；因此，所有组件都被合并在一起。通过这种特殊的结构，我们打算避免低流量区域，从而导致血栓形成和气体交换恶化。在血流量为5 L/min时，原型装置的气体传递性能（气体交换面积为1.5m^2，启动体积为400 ml）为氧气300 ml/min，二氧化碳250 ml/min。利用该装置对体重60公斤的山羊无功能心肺模型进行静脉旁路手术，可以满意地替代全心肺功能。在6小时的泵送过程中，山羊血流动力学参数保持较稳定，PaO_2血气数据维持在300 mmHg以上，PaCO_2血气数据维持在30 mmHg以下。我们也在开发一种抗血栓表面处理技术：共价肝素键合技术。虽然这项研究还不成熟，但我们相信在不久的将来我们可以将其付诸实践。