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Study of the proper management of total liquid ventilation and the development of the system for respiratory suport

全液体通气正确管理及呼吸支持系统开发的研究

基本信息

批准号：
06507003
负责人：
TAKANO Hisateru
金额：
$ 21.12万
依托单位：
National Cardiovascular Center Research Institute
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06507003/
关键词：
Liquid Ventilation Lipuid breathing perfluorocarbon perfluorochamical perfluorochemical Liquid Ventilation Breathing Perfluorocarbon

项目摘要

1. Initially, a liquid ventilator was developed which was controlled by volume-controlled with pressure limit mode, and total liquid ventilation was performed with it in rabbits. End-expiratory residual volume (EERV) was proved too excessive during total liquid ventilation at initial experiment when compared with the pressure-volume courve of perfluorocarbon measured with others rabbits.2. Weight-controlling total liquid ventilation with rabbits was carried out. The principal of this ventilation to regulate a tidal volume and the EERV was as follows ; the density of PFC is large and the weight of a liquid ventilated animal varies. Therefore, if a maximum and minimum weight are controlled, it follows that a TV and EERV can be controlled. The EERV was increased during liquid ventilation, but TV and ventilation cycle were kept the same. There was no change in PaO2, SaO2, and hemoglobin concentration, whereas PaCO2 and SvO2 deteriorated as the EERV increased. That is, increase in EERV harm … More s gas exchange as well as circulation. The most physiological level of the EERV was around functional residual capacity of liquid (FRC of liquid : FRCL).3. However, to reach the EERV of ERCL with relatively short time was very difficult. Expiration of PFC needs drawing force due to low recoil property. With conventional expiration such as siphon, troughs appear during expiration. These troughs seem to be caused by airway occlusion which may cause airway bleeding or uneven ventilation. We developed a new expiratory method in which difference for siphon became rapidly smaller as the expiration. Rather smooth expiration became feasible with the method.4. Total liquid ventilation with rabbits was carried out with this method on the condition that the EERV was lept as FRCL and a TV was kept constant small volume, but ventilation rate varied. The PaO2 and PaCO2 improved rate-responsively without metabolic acidosis.5. Total liquid ventilation with rabbits was considered that it was impossible to keep both PaCo2 and SvO2 physiologically. The research proved that there was a possibility that the total liquid ventilation could be maintained in difficult cases such as rabbits, and that the results might deny the conventional view for total liquid ventilation : total liquid ventilation must be maintained with large TV and small rate. Less

1.首先，我们研制了一种液体呼吸机，它是由容量控制和压力限制模式控制的，并在家兔身上进行了全液体通气。与其他兔测得的全氟碳压力-容积曲线相比，初步实验证明完全液体通气时呼气末残留量（EERV）过多。2.对家兔进行体重控制的全液体通气。这种通气调节潮气量和EERV的原理如下：PFC的密度大，液体通气动物的体重变化。因此，如果控制最大和最小重量，则可以控制TV和EERV。液体通气时EERV增加，而TV和通气周期保持不变。PaO 2、SaO 2和血红蛋白浓度无变化，而PaCO 2和SvO 2随EERV增加而恶化。也就是说，EERV危害增加 ...更多信息的气体交换和循环。EERV的最生理水平在液体功能残气量（FRC of liquid：FRCL）附近.然而，在相对较短的时间内达到ERCL的EERV是非常困难的。PFC的后坐力小，需要牵引力。对于诸如虹吸的常规呼气，在呼气期间出现波谷。这些波谷似乎是由气道阻塞引起的，气道阻塞可能导致气道出血或通气不均匀。我们提出了一种新的呼气方法，即虹吸差随着呼气时间的延长而迅速减小。相当顺利的呼气成为可行的方法。用此方法对家兔进行全液体通气，EERV与FRCL相同，TV保持恒定小容量，但通气量不同。PaO 2和PaCO 2在无代谢性酸中毒的情况下呈速率反应性改善。认为家兔全液体通气不可能同时保持PaCO_2和SvO_2的生理性。本研究证明了在困难的情况下如家兔，完全液体通气是可以维持的，并且该结果可能否定了关于完全液体通气的传统观点：必须以大TV和小速率维持完全液体通气。少