Totally Implantable Artificial Heart & Its Hemocompatibility

完全植入式人工心脏

• 批准号: 05044195
• 负责人: TAKANO Hisateru
• 金额: $ 6.08万
• 依托单位: National Cardiovascular Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05044195/
• 关键词: Totally implantable artificial heart; Electrohydraulic artificial heart; Electromechanical artificial heart; Centrifugal pump; Antithrombogenicity; Hemocompatibility; Animal experiment; Control-driving; 解剖学的適合性; 電気一機械式人工心臓; ハイブリッド組織; エネルギー伝送

The purposes of this international cooperative study are to develop totally implantable artificial hearts as well as to improve hemocompatibility of such devices through cooperative experimental study and exchanging scientific ideas, and discussing technological subjects.Progresses of the technology were reported as below ;1.Basic research and development of components of a totally implantable artificial heart.An electrohydraulic total artificial heart was developed and improvements of output performance and efficiency of the pump system was carried out.Another unique total artificial heart was also developed composed of a single centrifugal pump and 2 three-way valves.An electro-mechanical artificial heart has been evaluated in a mock loop.Research development of a moving-actuator-type total artificial heart was also conducted.A transcutaneous energy transfer system and internal batteries were also investigated.Concerning blood pumps, bileaflet-type and jellyfish-like-shaped valves we … More re studied for application as artificial valves, and configuration of blood chambers of a sactype pump and a centrifugal pump was studied.2.Basic research in hemocompatibility of artificial organs and its application to blood pumps.Improvements of antithrombogenicity of a blood pump were carried out.They were development of an antithrombogenic polyurethane, application of a bioengineering technology of hybrid tissues, endothelial cell seeding onto extracellular matrix on polyurethane sheets, and lumbrokinase-immobilization on the surface of a blood pump.basic research activities were molecular biological studies on tissue factor pathway inhibitor and protein and calcium adsorption of the surface in a total artificial heart and a left ventricular assist device.3.Evaluation of the performance of artificial hearts.An electrohydraulic total artificial heart and a centrifugal pump were applied to experimental animals and satisfactory in vivo performances were proved.A moving-actuator-type artificial heart was implanted in calves and sheep. Less

本次国际合作研究的目的是通过合作实验研究、交流科学思想、探讨技术课题，研制完全植入式人工心脏，改善人工心脏的血液相容性，现将该技术进展报告如下：1.全植入式人工心脏部件的基础研究与开发研制了电液式全植入式人工心脏，对泵系统的输出性能和效率进行了改进，并研制了一种由单泵和两个三通阀组成的新型全人工心脏，在模拟回路中对机电式人工心脏进行了评价。型全人工心脏，并对经皮能量传输系统和内部电池进行了研究。双叶型和鱼形瓣翼 ...更多信息 2.人工器官的血液相容性及其在血泵中的应用基础研究：对血泵的抗血栓性能进行了改进，包括抗血栓聚氨酯的研制，组织杂交生物工程技术的应用，将内皮细胞接种到聚氨酯片上的细胞外基质上，和蚓激酶基本研究活动是对全人工心脏和左心室辅助心脏中组织因子途径抑制剂和表面蛋白质及钙吸附的分子生物学研究。3.人工心脏的性能评价：将电液式全人工心脏和离心泵应用于实验动物，证明其在体性能良好;将运动驱动型人工心脏植入牛和羊体内，证明其在体性能良好。少

项目成果

Tatsumi E,et al.: "Rapid conversion of systemic flow pattern from pulsatile to non-pulsatile in conscious goats" Progress in Microcirculation Research,(ed Niimi H et al.),Elsevier Science,Oxford. 463-467 (1994)

Tatsumi E 等人：“有意识的山羊全身血流模式从脉动到非脉动的快速转换”微循环研究进展，（Niimi H 等人编），Elsevier Science，牛津。

Taenaka Y: "Development of a pulsatile and a nonpulsatile artificial heart system at the National Cardiovascular Center Japan" Progress in the Artificial Heart. 157-172 (1995)

Taenaka Y：“日本国家心血管中心开发搏动和非搏动人工心脏系统”人工心脏的进展。

Park YH,et al.: "The animal experiments of total artificial heart at the national cardiovascular center in japan" Korean J Thoracic Cardiovas Surg. 27. 824-832 (1994)

Park YH等：“日本国家心血管中心全人工心脏的动物实验”韩国胸心血管外科杂志。

Taenaka Y,et al.: "Research and development of artificial heart for chronic use in national cardiovascular center" Artificial Heart 1993. 293-296 (1994)

Taenaka Y,et al.：“国家心血管中心长期使用的人工心脏的研究和开发”Artificial Heart 1993. 293-296 (1994)

Takano H. et al.: "Clinical experience with ventricular assist system in Japan." Ann Thorac Surg. 55. 250-256 (1993)

Takano H. 等人：“日本心室辅助系统的临床经验。”