Totally Implantable artificial heart & its hemocompatibility

全植入式人工心脏

• 批准号: 04044192
• 负责人: TAKANO Hisateru
• 金额: --
• 依托单位: National Cardiovascular Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Overseas Scientific Survey.
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04044192/
• 关键词: Artificial heart; Hemocopatibility; Total implantation; Electrohydraulic artificial heart; Electromechanical artificial heart; Hybrid tissue; Centrifugal pump; Energy transfer

The purposes of this international cooperative study are exchanging scientific ideas and discussing technological subjects to develop a totally implantable artificial heart. The technology includes the improvement of hemocompatibility, mainly antithrombogenicity, of a device and the establishment of basic technology for the development. In this fiscal year, The Second Korea-Japan Joint Conference was held in Suita, Osaka, Japan as a workshop to reach for the purposes and progresses of the technology were reported.1.Basic research and development of components of a implantable artificial heart.An electrohydraulic actuator to activate a total artificial heart was developed and improvements of output performance of the pump system was carried out in National Cardiovascular Center N(NCVC) of Japan. In Hokkaido Tokai University, an electro-mechanical ventricular assist device has evaluated in a mock loop. Research development of a moving-actuator-type total artificial heart was conducted in … More Seoul National University (SNU) in Korea. A transcutaneous energy transfer system was also designed and its in vitro and in vivo characteristics were evaluated in Japan. Concerning blood pumps, bilcaflet-type of SNU and jellyfish-like-shaped of Tokyo University polymer valves were investigated for application as artificial valves, and configuration of blood chambers of a sac-type pump of SNU and a centrifugal pump of NCVC was studied flow visualization techmiques.2.Basic research in hemocompatibility of artificial organs and its application to blood pumps.In order to improve the antithrombogenicity of a blood pump, a few investigations were carried out. They were development of an antithrombogenic polyurethane, application of a bioengineering technology of hybrid tissues, endothelial cell seeding onto extracellular matrix on polyurethane sheets, and lumbrokinase- immobilization on the surface of a blood pump. The first two were accomplished Japan and the latter two were in Korea. Basic research activities were molecular biological studies on tissue factor pathway inhibitor and adsorption of the surface in a total artificial heart and a left ventricular assist device.3.Evaluation of the performance of artificial hearts.An electrohydraulic total artificial heart and a centrifugal pump were applied to experimental animals and satisfactory in vivo performances were proved in NCVC. A moving-actuator-type artificial heart of SNU was implanted in a calf and the circulation of the animal was maintained for 10 hours. Postoperative management of an animal with an artificial heart was simulated by a computer in SNU. Less

这项国际合作研究的目的是交流科学思想和讨论技术主题，以开发完全植入式人工心脏。该技术包括改善器械的血液相容性，主要是抗血栓性，并建立开发的基础技术。在本财政年度，第二次韩日联席会议在大坂吹田举行，1.植入式人工心脏部件的基础研究和开发。在国立心血管中心N（NCVC）。在北海道东海大学，一个机电心室辅助装置进行了评估，在一个模拟循环。年进行了一种移动驱动器型全人工心脏的研究开发。 ...更多信息 韩国首尔国立大学。还设计了经皮能量转移系统，并在日本对其体外和体内特性进行了评价。在血泵方面，研究了SNU的牛背瓣型和东京大学的鱼形高分子瓣膜作为人工瓣膜的应用，并利用流动显示技术研究了SNU的囊型泵和NCVC的离心泵的血室结构。2.人工器官血液相容性的基础研究及其在血泵中的应用。进行了一些调查。它们是抗血栓形成聚氨酯的开发，杂交组织的生物工程技术的应用，内皮细胞接种到聚氨酯片上的细胞外基质上，以及蚓激酶固定在血泵表面上。前两个是在日本完成的，后两个是在韩国完成的。基础研究活动包括组织因子途径抑制剂的分子生物学研究、全人工心脏和左心室辅助装置表面吸附的研究。3.人工心脏性能的评价将电液全人工心脏和离心泵应用于实验动物，在NCVC中证明了满意的体内性能。将SNU的移动致动器型人工心脏植入小牛体内，并维持动物的循环10小时。在上海国立大学用计算机模拟了一只装有人工心脏的动物的术后管理。少

项目成果

Yoshiyuki Taenaka, Kazushige Inoue, Toru Masuzawa, Kenji Araki, Masayuki Sakaki, Hisateru Takano, et: "Infuluence of an Impeller Centrifugal pump on Blood Components in Chronic Animal Experiments." Reprint from ASAIO TRANSACTIONS. 38. M577-M579 (1992)

Yoshiyuki Taenaka、Kazushige Inoue、Toru Masuzawa、Kenji Araki、Masayuki Sakaki、Hisateru Takano 等：“叶轮离心泵对慢性动物实验中血液成分的影响”。

K.Enjyoji,M.Emi,T.Mukai,H.Kato: "CDNA Cloning and expression of rat tissue factor path-way inhibitor(TFPI)." J.Biochem. 111. 681-687 (1992)

K.Enjyoji、M.Emi、T.Mukai、H.Kato：“大鼠组织因子途径抑制剂 (TFPI) 的 CDNA 克隆和表达。”

Kou Imachi,Kunihiko Mabuchi,TsuneoChinzei,Yusuke Abe,Kaoru Imanishi,Takumi Yonezawa,Akimasa Kouno,et al: "Fabrication of a Jellyfish Valve for Use in an Artiticial Heart." ASAIO Journal. 38. M237-M242 (1992)

Kou Imachi、Kunihiko Mabuchi、Tsuneo Chinzei、Yusuke Abe、Kaoru Imanishi、Takumi Yonezawa、Akimasa Kouno 等人：“用于人工心脏的水母瓣膜的制造”。