Totally Implantable artificial heart & its hemocompatibility

全植入式人工心脏

• 批准号: 04044192
• 负责人: TAKANO Hisateru
• 金额: --
• 依托单位: National Cardiovascular Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Overseas Scientific Survey.
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04044192/
• 关键词: Artificial heart; Hemocopatibility; Total implantation; Electrohydraulic artificial heart; Electromechanical artificial heart; Hybrid tissue; Centrifugal pump; Energy transfer

The purposes of this international cooperative study are exchanging scientific ideas and discussing technological subjects to develop a totally implantable artificial heart. The technology includes the improvement of hemocompatibility, mainly antithrombogenicity, of a device and the establishment of basic technology for the development. In this fiscal year, The Second Korea-Japan Joint Conference was held in Suita, Osaka, Japan as a workshop to reach for the purposes and progresses of the technology were reported.1.Basic research and development of components of a implantable artificial heart.An electrohydraulic actuator to activate a total artificial heart was developed and improvements of output performance of the pump system was carried out in National Cardiovascular Center N(NCVC) of Japan. In Hokkaido Tokai University, an electro-mechanical ventricular assist device has evaluated in a mock loop. Research development of a moving-actuator-type total artificial heart was conducted in … More Seoul National University (SNU) in Korea. A transcutaneous energy transfer system was also designed and its in vitro and in vivo characteristics were evaluated in Japan. Concerning blood pumps, bilcaflet-type of SNU and jellyfish-like-shaped of Tokyo University polymer valves were investigated for application as artificial valves, and configuration of blood chambers of a sac-type pump of SNU and a centrifugal pump of NCVC was studied flow visualization techmiques.2.Basic research in hemocompatibility of artificial organs and its application to blood pumps.In order to improve the antithrombogenicity of a blood pump, a few investigations were carried out. They were development of an antithrombogenic polyurethane, application of a bioengineering technology of hybrid tissues, endothelial cell seeding onto extracellular matrix on polyurethane sheets, and lumbrokinase- immobilization on the surface of a blood pump. The first two were accomplished Japan and the latter two were in Korea. Basic research activities were molecular biological studies on tissue factor pathway inhibitor and adsorption of the surface in a total artificial heart and a left ventricular assist device.3.Evaluation of the performance of artificial hearts.An electrohydraulic total artificial heart and a centrifugal pump were applied to experimental animals and satisfactory in vivo performances were proved in NCVC. A moving-actuator-type artificial heart of SNU was implanted in a calf and the circulation of the animal was maintained for 10 hours. Postoperative management of an animal with an artificial heart was simulated by a computer in SNU. Less

这次国际合作研究的目的是交流科学思想，讨论技术主题，以开发完全可植入的人工心脏。该技术包括改善设备的血液相容性，主要是抗凝血性，以及为开发建立基础技术。本财政年度，第二届韩日联合会议在日本大阪水田举行，作为研讨会，以达到该技术的目的和进展。1.植入式人工心脏部件的基础研究和开发。日本国家心血管中心(NCVC)开发了一种用于激活全人工心脏的电液致动器，并对泵系统的输出性能进行了改进。在北海道东海大学，一种电子机械的心脏辅助装置已经在模拟回路中进行了评估。…研制了一种运动驱动器型全人工心脏更多的首尔国立大学(SNU)在韩国。日本还设计了经皮能量转移系统，并对其体内外特性进行了评价。在血泵方面，研究了SNU双管型和东京大学水母状聚合物瓣作为人工瓣膜的应用，并对SNU的囊式泵和NCVC的离心泵的血腔结构进行了流动显示技术研究。2.人工器官的血液相容性及其在血泵中的应用基础研究。它们是：抗血栓形成聚氨酯的开发，杂交组织生物工程技术的应用，内皮细胞种植到聚氨酯薄片上的细胞外基质上，以及血泵表面的蚯蚓激酶固定化。前两次是在日本完成的，后两次是在韩国完成的。基础研究工作包括组织因子途径抑制物的分子生物学研究以及人工心脏和左心辅助装置的表面吸附。3.人工心脏性能的评价。将电液压全人工心脏和离心泵应用于实验动物，在NCVC中获得了满意的体内性能。将SNU的运动驱动器型人工心脏植入小牛体内，维持循环10h。在SNU用计算机模拟了人工心脏动物的术后管理。较少

项目成果

Yoshiyuki Taenaka, Kazushige Inoue, Toru Masuzawa, Kenji Araki, Masayuki Sakaki, Hisateru Takano, et: "Infuluence of an Impeller Centrifugal pump on Blood Components in Chronic Animal Experiments." Reprint from ASAIO TRANSACTIONS. 38. M577-M579 (1992)

Yoshiyuki Taenaka、Kazushige Inoue、Toru Masuzawa、Kenji Araki、Masayuki Sakaki、Hisateru Takano 等：“叶轮离心泵对慢性动物实验中血液成分的影响”。

K.Enjyoji,M.Emi,T.Mukai,H.Kato: "CDNA Cloning and expression of rat tissue factor path-way inhibitor(TFPI)." J.Biochem. 111. 681-687 (1992)

K.Enjyoji、M.Emi、T.Mukai、H.Kato：“大鼠组织因子途径抑制剂 (TFPI) 的 CDNA 克隆和表达。”

Kou Imachi,Kunihiko Mabuchi,TsuneoChinzei,Yusuke Abe,Kaoru Imanishi,Takumi Yonezawa,Akimasa Kouno,et al: "Fabrication of a Jellyfish Valve for Use in an Artiticial Heart." ASAIO Journal. 38. M237-M242 (1992)

Kou Imachi、Kunihiko Mabuchi、Tsuneo Chinzei、Yusuke Abe、Kaoru Imanishi、Takumi Yonezawa、Akimasa Kouno 等人：“用于人工心脏的水母瓣膜的制造”。