Totally implantable artificial heart & its hemocompatibility

全植入式人工心脏

• 批准号: 03044173
• 负责人: TAKANO Hisateru
• 金额: --
• 依托单位: National Cardiovascular Center
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Overseas Scientific Survey.
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03044173/
• 关键词: Totally implantable total artificial heart; Centrifugal pump; Biomaterial; Hemocompatibility; Photoreactive chemistry; Endothelial cell; Lumbrokinase; Polyurethane valve

Present problems in the development of totally implantable total artificial heart were discussed especially focusing on the antithrombogenesity. In the national cardiovascular center, electrohydraulic type total artificial heart is under development. The merit of this system is that both ventricles can be separately implanted. However, energy loss to reverse the motor rotation is a problem to be solved in this system. To promote the antithrombogenesity of the pump, a novel surface process technology based on surface photoreactive chemistry is also under development. In the university of Tokyo, a unique total artificial heart is under development. This system is composed of a single centrifugal pump (CFP) and two three-way valves. One port of each three-way valve is connected to the inlet and outlet of a CFP, respectively. The other two ports of each valve are connected to the right and left atrium, p ulmonary artery and aorta. The CFP can perfuse the pulmonary and systemic circulation alternately with pulsatile flow by switching the two three-way valves. Blood mixture in the CFP and antithrombogenesity are problems in this system. In Seoul national university, a moving-actuator type total artificial heart is under development. Animal survived for 100 hours with this system. Polymer surface modification with endothelial cells and proteolytic enzyme is being examined to promote antithrombogenesity.

讨论了目前全植入式人工心脏发展中存在的问题，特别是抗血栓形成方面的问题。在国家心血管中心，电液式全人工心脏正在研制中。该系统的优点是两个心室可以单独植入。然而，使电动机反转的能量损失是该系统中要解决的问题。为了提高泵的抗血栓形成能力，一种基于表面光反应化学的新型表面处理技术也在开发中。东京大学正在开发一种独特的全人工心脏。该系统由一台离心泵（CFP）和两个三通阀组成。每个三通阀的一个端口分别连接到CFP的入口和出口。每个瓣膜的另外两个端口连接到右心房和左心房、肺动脉和主动脉。CFP通过切换两个三通阀，以脉动流交替灌注肺循环和体循环。CFP中的血液混合和抗血栓形成是该系统的问题。在首尔国立大学，正在开发一种移动致动器型全人工心脏。动物在该系统中存活了100小时。用内皮细胞和蛋白水解酶修饰聚合物表面以促进抗血栓形成。

项目成果

Satoshi Niu,et al.: "Control of cellular orientation in two-dimensional tissue formation:surface topplogic effect of collagen fibers on endothelialization." Trans Am Soc Artif Intern Organs. 37. M441-M442 (1991)

Satoshi Niu 等人：“二维组织形成中细胞方向的控制：胶原纤维对内皮化的表面拓扑效应”。

Sang H.Lee,et al.: "Development of a totally implantable total artificial heart controller." Trans Am Soc Artif Intern Organs. 37. M505-M507 (1991)

Sang H.Lee 等人：“开发完全植入式全人工心脏控制器。”

Yoshiyuki Taenaka, et al.: "Chronic evaluation of a compact nonseal magnet pump as a nonpulsatile pump for long-term use." Trans Am Soc Artif Intern Organs. 37. M243-M245 (1991)

Yoshiyuki Taenaka 等人：“对紧凑型非密封磁力泵作为长期使用的非脉动泵进行长期评估。”

Kou Imachi,et al.: "A new pulsatile total heart using a single centrifugal pump." Trans Am Soc Artif Intern Organs. 37. M242-M243 (1991)

Kou Imachi 等人：“使用单个离心泵的新型脉动全心脏。”

Satoshi Niu, et al.: "Control of cellular oriention in two-dimensional tissue formation : surface topplogic effect of collagen fibers on endothelialization." Trans Am Soc artif Intern Organs. 37. M441-M442 (1991)

Satoshi Niu 等人：“二维组织形成中细胞方向的控制：胶原纤维对内皮化的表面拓扑效应。”