Studies on Biosynthesis of Bioactive Compounds produced by Microalgae
微藻生物活性化合物的生物合成研究
基本信息
- 批准号:03660206
- 负责人:
- 金额:$ 1.28万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (C)
- 财政年份:1991
- 资助国家:日本
- 起止时间:1991 至 1992
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Biosynthesis of polyether macrolide goniodomin A, which was produced by dinoflagellate Alexandrium hiranoi, was investigated by feeding experiments. Feeding experiments were carried out by adding [1-^<13>C_1],[2-^<13>C_1], or [1,2-^<13>C_2]-sodium acetate, Methyl- ^<13>C-methionine, and [1-^<13>C_1]-glucose of cultures of Alexandrium hiranoi. ^<13>C NMR signals of goniodomin A were assigned by analyses of 1D and 2D NMR spectra. Out of 46 carbons of goniodomin A 40 carbons(c or m in Fig. 1) were labeled by sodium acetate. Only one carbon(M in Fig. 1) was also labeled by methionine. Two carbons(A and B in Fig. 1) labeled by glucose slightly showed enhancement of signal intensities in ^<13>C NMR. The labeling patterns(Fig. 1) suggested unusual biosynthetic pathway different from polyketides pathway.
通过摄食实验研究了沟鞭藻Alexandiumhiranoi产生的聚醚大环内酯goniodomin A的生物合成。通过添加[1-^<13>C_1]、[2-^<13>C_1]或[1,2-^<13>C_2]-乙酸钠、甲基- ^<13>C-甲硫氨酸和[1-^<13>C_1]-葡萄糖对Alexandiumhiranoi培养物进行饲养实验。通过<13>对1D和2D NMR谱的分析,对goniodomin A的13 C NMR信号进行了归属。在goniodomin A的46个碳中,40个碳(图1中的c或m)被乙酸钠标记。仅一个碳(图1中的M)也被甲硫氨酸标记。葡萄糖标记的两个碳(图1中的A和B)在13 C NMR中略微显示出信号强度的增强<13>。标记模式(图1)表明不寻常的生物合成途径不同于聚酮途径。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MURAKAMI Masahiro其他文献
MURAKAMI Masahiro的其他文献
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{{ truncateString('MURAKAMI Masahiro', 18)}}的其他基金
Organic Transformations Exploiting Solar Energy as the Driving Force
利用太阳能作为驱动力的有机转型
- 批准号:
24655077 - 财政年份:2012
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Developement of New Synthetic Methods for Nitrogen-containing Compounds
含氮化合物合成新方法的开发
- 批准号:
23350041 - 财政年份:2011
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Study of heat satability mechanism of 5'-AMPdeaminase in dried Iwa-nori
干岩海苔5-AMP脱氨酶热稳定性机制研究
- 批准号:
20580224 - 财政年份:2008
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Activation of Carbon-Carbon Bonds by Transition Metals
过渡金属对碳-碳键的活化
- 批准号:
19205013 - 财政年份:2007
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
In vivo 3 dimensional cartilage tissue engineering by adipose derived stem cells
利用脂肪干细胞进行体内 3 维软骨组织工程
- 批准号:
15591907 - 财政年份:2003
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Studies on Cyanobacterial Cyderophores
蓝藻细胞细胞的研究
- 批准号:
14360120 - 财政年份:2002
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Insertion of Unsaturarel Organic Compounds into Carbon-Carbon Bonds
将不饱和有机化合物插入碳-碳键
- 批准号:
12450362 - 财政年份:2000
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Utilization of antialgal compounds produced by lyticbacteria of cyanobacteria
蓝藻溶菌菌产生的抗藻化合物的利用
- 批准号:
12460090 - 财政年份:2000
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
ANALYSIS OF THE LYTIC MECHANISM OF FILLAMENTOUS CYANOBACTERIA BY THE LITIC BACTERIA
细菌裂解丝状蓝藻的机理分析
- 批准号:
10460092 - 财政年份:1998
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Studies on search of protease inhibitors in blue-green algae and biosynthetic pathways
蓝绿藻蛋白酶抑制剂的寻找及生物合成途径研究
- 批准号:
05453172 - 财政年份:1993
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)