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Neuronal mechanism generating vertical eye position signals.

产生垂直眼睛位置信号的神经元机制。

基本信息

批准号：
03670050
负责人：
YOSHIDA Kaoru
金额：
$ 1.28万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1991
资助国家：
日本
起止时间：
1991 至 1992
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03670050/
关键词：
vertical eye movement eye position vestibular nucleus interstitial nucleus of Cajal カハ-ル間質核舌下神経前位核

项目摘要

The vestibular nucleus (VN) and the interstitial nucleus of Cajal (INC) contain neurons with activity related to vertical eye movement. To examine a possible interaction between the two nuclei, projection of INC neurons to VN and vestibular input to these neurons were studied in the alert cat.Sixty-two INC neurons with activity related to vertical eye position were tested for the response to stimulation of the ipsilateral VN. Forty-one had a downward and 21 an upward on-direction (to be called downward and upward neurons, respectively). Thirteen of 41 downward neurons were antidromically activated following stimulation of the ipsilateral VN with thresholds 36 to 220 muA. None of 21 upward neurons showed antidromic responses. Histological study showed that the stimulation sites had been in the ventral part of VN at the level of the Vlth nucleus. All the downward INC neurons antidromically activated from VN responded orthodromically to stimulation of the contralateral vestibular nerve at disynaptic latencies (1.3 to 2.0 msec). We suggest that secondary VN neurons carrying vertical eye position signals make excitatory connections with contralateral downward INC neurons which in turn send the signal ipsilaterally to VN. This neural pathway may form an important part of the neural circuitry responsible for the generation of vertical eye position signals.

前庭核（VN）和Cajal间质核（INC）含有与垂直眼球运动相关的神经元。要检查可能的两个核之间的相互作用，INC神经元的VN和前庭输入这些神经元的投影进行了研究，在警觉猫。六十二INC神经元与活动相关的垂直眼位置进行了测试，以刺激同侧VN的反应。41个神经元有向下的方向，21个神经元有向上的方向（分别称为向下和向上神经元）。41个下行神经元中有13个在刺激同侧VN后被逆向激活，阈值为36至220 μ A。21个上行神经元均无逆向反应。组织学观察表明，电刺激部位在第Ⅴ核水平的VN腹侧部。所有从VN逆向激活的向下INC神经元在双突触潜伏期（1.3 - 2.0毫秒）对刺激对侧前庭神经作出顺向反应。我们认为，携带垂直眼位置信号的次级VN神经元与对侧向下INC神经元产生兴奋性联系，后者又将信号发送到同侧VN。该神经通路可以形成负责产生垂直眼睛位置信号的神经回路的重要部分。