Effect of excessive intake of trace elements caused by taking dietary supplements on senile neuropathy

所分析的一些植物补充剂含有高浓度的铝（Al）和锰（Mn）。已知铝和锰具有神经毒性作用。我们研究了长期暴露于铝和/或锰对动物行为的影响。长期暴露于Al或Mn会抑制小鼠的轮跑活动。长期暴露于Al对大鼠的被动回避行为没有影响，而Mn对大鼠的被动回避行为有剂量依赖性的抑制作用。我们进行了一项问卷调查，调查膳食补充剂的使用情况和成年人的饮食习惯。服用补充剂的人比不服用的人有更健康的饮食习惯。66%的膳食补充剂使用者每天服用补充剂。食物中的微量元素和膳食补充剂中的微量元素可能会增加过量摄入的风险。

Some of botanical supplements analyzed contained high concentration of Aluminium (Al) and manganese (Mn). Al and Mn are known to have neurotoxic effects. We investigated the effect of chronic exposure to Al and/or Mn on animal behavior. Chronic exposure to Al or Mn inhibited wheel-running activity in mice. Chronic exposure to Al did not affect the passive avoidance performance, but Mn inhibited avoidance performance in dose-dependent manner in rats. We conducted a questionnaire survey to investigate the use of dietary supplements and dietary habits in adults. Supplement users had more healthy eating habits than the non-users. 66 % of the dietary supplement users took the supplements every day. The risk of excessive intake might be increased by trace elements in food plus that in dietary supplements.