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Saccade-related inputs to the saccade generator : an intracellular study in alert cats

扫视生成器的与扫视相关的输入：警觉猫的细胞内研究

基本信息

批准号：
09680811
负责人：
YOSHIDA Kaoru
金额：
$ 2.18万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

项目摘要

Omnipause neurons (OPNs) are midline pontine neurons that are thought to control a number of oculomotor behaviors, especially saccades. Intracellular recordings were made from OPNs in alert cats to elucidate saccade-associated postsynaptic events and thereby determine what patterns of afferent discharge impinge upon OPNs to cause their saccadic inhibition. The membrane potential of OPNs exhibited steep hyperpolarization before each saccade which lasted for the whole period of the saccade. The hyperpolarization was reversed to depolarization by intracellular injection of C1- ions, indicating it consisted of inhibitory postsynaptic potentials (IPSPs). The duration of the hyperpolarization was almost equal to the duration of the saccades. The time course of the hyperpolarization was similar to that of the radial eye velocity except for the initial phase. During the falling phase of eye velocity, the correlation between the instantaneous amplitude of hyperpolarization and the instantaneous … More eye velocity was highly significant. The amplitude of hyperpolarization at the eye velocity peak was significantly correlated with the peak eye velocity. The time integral of the hyperpolarization was correlated with the amplitude of saccades. The initial phase disparity between the hyperpolarization and eye velocity was due to the relative constancy of peak time of the initial steep hyperpolarization regardless of the later potential profile that covaried with the eye velocity. The hyperpolarization led the beginning of saccades by 16 ms, which is longer than the lead time for medium-lesd burst neurons. These results demonstrate that the pause of activity in OPNs is caused by LPSPs initiated by an abrupt, intense input and maintained, for the whole duration of saccade, by afferents conveying eye velocity signals. We suggest that the initial sudden inhibition originates from central structures such as the superior colliculus and that the eye velocity-related inhibition originates from the burst generator in the brain stem. Less

全暂停神经元（Omnipause neurons，OPN）是脑桥中线神经元，被认为控制许多眼球运动行为，特别是扫视。细胞内记录从OPN在警觉猫阐明扫视相关的突触后事件，从而确定什么样的传入放电模式的冲击OPN，导致他们的扫视抑制。OPN的膜电位在每次眼跳前均呈现陡峭的超极化，并持续整个眼跳过程。细胞内注射C1-离子可使超极化逆转为去极化，表明其由抑制性突触后电位（IPSPs）组成。超极化的持续时间几乎等于扫视的持续时间。超极化的时间过程与桡眼速度的时间过程相似，除了初始阶段。在眼速下降相，超极化瞬时幅度与瞬时 ...更多信息眼速度是非常显著的。眼速度峰值处的超极化幅度与眼速度峰值显著相关。超极化的时间积分与眼跳幅度相关。超极化和眼速度之间的初始相位差是由于初始陡峭超极化的峰值时间的相对恒定性，而不管与眼速度共变的后期电位曲线。超极化导致扫视开始16毫秒，这是比中-lesd爆发神经元的领先时间长。这些结果表明，在OPNs的活动暂停引起的LPSP发起的突然，强烈的输入和维护，在整个持续时间的扫视，由传入传递眼速度信号。我们认为，最初的突然抑制起源于上级丘等中央结构，而与眼睛速度相关的抑制起源于脑干中的爆发发生器。少