Surface Chemistry meets Cell Biology: Molecular Level Control of Surface Architecture for Cell Adhesion and Migration

表面化学与细胞生物学的结合：细胞粘附和迁移表面结构的分子水平控制

• 批准号: DP0772356
• 负责人: Prof John Gooding
• 金额: $ 25.67万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-04-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0772356
• 关键词: Surface; Chemistry; meets; Cell; Biology

Biotechnological applications such as tissue engineering, bone supports, implantable materials, cell assays and biosensors all require detailed knowledge of how cells interact with their environment. The proposed research aims to provide this knowledge by developing unique modified surfaces to investigate white blood cell migration and adhesion. Additional expected outcome will contribute to our understanding of the many fundamental cellular processes such as cell growth, differentiation and cell death as well as the molecular basis of diseases such as inflammation, cancer, cardiovascular diseases and wound healing. This research program will establish Australia as a leading force in this new research field.

生物技术的应用，如组织工程，骨支持，植入材料，细胞测定和生物传感器都需要详细的知识，细胞如何与他们的环境相互作用。拟议的研究旨在通过开发独特的改性表面来研究白色血细胞的迁移和粘附来提供这方面的知识。额外的预期结果将有助于我们理解许多基本的细胞过程，如细胞生长，分化和细胞死亡，以及疾病的分子基础，如炎症，癌症，心血管疾病和伤口愈合。这项研究计划将使澳大利亚成为这一新研究领域的主导力量。