The implications of focal adhesion organization on signal transduction

粘着斑组织对信号转导的影响

• 批准号: nhmrc : 630545
• 负责人: Prof John Gooding
• 金额: $ 37.72万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/implications-focal-adhesion-signal-transduction/77926
• 关键词: implications; focal; adhesion; organization; signal

The areas of a cell's attachment to their surroundings are known as focal adhesion. Apart from linking the inside and outside of a cell, focal adhesions act as a communication centre transmitting incoming and outgoing signals. How focal adhesions themselves are organized is currently not known. We propose to adhere cells to model surfaces to control the protein and membrane structure of focal adhesions and measure how focal adhesion structure affects cell communication.

细胞与周围环境的粘附区域称为粘着斑。除了连接细胞内外，粘着斑还充当传递传入和传出信号的通信中心。目前尚不清楚局灶性粘连本身是如何组织的。我们建议将细胞粘附到模型表面，以控制粘着斑的蛋白质和膜结构，并测量粘着斑结构如何影响细胞通讯。