Assessment of exposure to solvent mixture by biological monitoring

通过生物监测评估溶剂混合物的暴露情况

• 批准号: 05304030
• 负责人: IKEDA Masayuki
• 金额: $ 4.35万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Co-operative Research (A)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05304030/
• 关键词: Analysis of biological specimen; Biological monitoring; Exposure evaluation; Solvent mixture; Occupational Health; トルエン; 生体影響; メチルエチルケトン; イソプロピルアルコール; ヘキサン

Ikeda reviewed existing reports on combined exposure to solvents and concluded that no metabolic interaction between the solvents is likely to occure when the exposured are below current occupational exposure limits.Such conclusion was confirmed when industrial workers were biologically monitored after combined exposure to stirene and acetone, toluene and xylene, toluene and MEK,or toulene and IPA(Ikeda, Iguchi, Kawai).Takeuchi observed toluenne-induced suppression of hexane metabolism in rats as well as in factory workers.Sato employed rats in which solvent metabolism was induced by repeated oral administration of ethanol, and confirmed both in vitro and in vivo that the metabolism of trichloroethylene and chloroform was modified by the induction only when the exposure was high whereas metabolism of methylchloroform was affected by the induction regardless of exposure intensity.Ogata made evaluation of biological monitoring in comparison with traditional environmental monitoring, and proposed a version of the additiveness formula applicable to biological monitoring of combined exposure to solvents.

池田回顾了现有的关于溶剂联合暴露的报告，并得出结论，当暴露量低于目前的职业暴露限值时，溶剂之间不可能发生代谢相互作用。当工业工人在同时暴露于乙烯和丙酮、甲苯和二甲苯、甲苯和MEK或甲苯和IPA后进行生物学监测时，证实了这一结论（Ikeda, Iguchi, Kawai）。Takeuchi在大鼠和工厂工人中观察到甲苯诱导的己烷代谢抑制。佐藤采用反复口服乙醇诱导溶剂代谢的大鼠，在体外和体内均证实，三氯乙烯和氯仿的代谢仅在暴露量高时才被诱导改变，而甲基氯仿的代谢无论暴露强度如何都受到诱导的影响。Ogata对生物监测与传统环境监测进行了对比评价，提出了一种适用于溶剂联合暴露生物监测的加性公式。

项目成果

Ikeda M: "Complex exposures:Potentials for assessing integrated exposures." Clin Chem. 40. 1444-1447 (1994)

Ikeda M：“复杂风险：评估综合风险的潜力。”

Takeuchi, Y.et al.: "Modification of metabolism and neurotoxicity of hexane by co-exposure of toluene." Int Arch Occup Environ Health. 65. S227-S230 (1993)

Takeuchi, Y.等人：“通过与甲苯共同暴露来改变己烷的代谢和神经毒性。”

Kawai T et al.: "Comparative evaluation of blood and urine analysis as a tool for biological monitoring of n-hexane and toluene" Int Arch Occup Environ Health. 65. S123-S126 (1993)

Kawai T 等人：“血液和尿液分析作为正己烷和甲苯生物监测工具的比较评估”Int Arch Occup Environ Health。

Chen Z et al.: "Exposure of workers to a mixture of toluene and xylenes.I.Effects." Occup Environ Med. 51. 47-49 (1994)

Chen Z 等人：“工人接触甲苯和二甲苯的混合物。I.影响。”

Ikeda, M.: "Complex exposures : Potentials for assessing integrated exposures." Clin Chem. 40. 1444-1447 (1994)

Ikeda, M.：“复杂风险：评估综合风险的潜力。”