Serological study on echinococcosis and cysticercosis

包虫病、囊尾蚴病的血清学研究

• 批准号: 06044089
• 负责人: ITO Akira
• 金额: $ 3.14万
• 依托单位: Gifu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06044089/
• 关键词: Parasitic diseases; Echinococcosis; Cysticercosis; Serodiagnosis

The major products on the "Serological study on echinococcosis and cysticercosis in 1994", financially supported by a Grant-in Aid for Scientific Research (the Joint Research, International Scientific Research Program) are as follows.1. Differentiation of active cases from inactive cases in alveolar echinococcosis : Antibody response against the previously undescribed epitope, Em18, is a good marker for the presence of active lesions in alveolar echinococcosis. This work has been published in the two papers : the 1st is by Ito & Schantz (1993), the 2nd by Ito, Schantz & Wilson (1995).2. Differentiation of alveolar echinococcosis from other parasitic diseases including cystic echinococcosis : Antibody response against Em18 is good marker for alveolar echinococcosis, whereas that against Em16 is for cystic echinococcosis. This work has been published in several papers : the 1st is by Ito et al. (1993), the 2nd by Ito, Wang & Liu (1993), the 3rd by Ito et al. (1994), the 4th by Wen et al. (1995). Three other papers are just submitted.3. The establishment of a new ELISA system : Partially purified Em18 and Em16 enriched fraction is highly useful for differentiation of active alveolar echinococcosis from other parasitic diseases including cystic echinococcosis. This work is under preparation for publication.A total of 13 papers on echinococcosis and cysticercosis have been published or in press and other three have been submitted for publication and another one is under preparation for publication in the international journals. There are some other minor papers on experimental cysticercosis. Several review papers on echinococcosis and cysticercosis in English and Japanese also have been published or in press.These products including unpublished collaboration work are highly informative and fruitful for further collaboration project on "Molecular-Immuno-Biology of Echinococcosis and Cysticercosis" which starts from 1995 for three years.

“1994年棘球蚴病和囊虫病的血清学研究”科研资助项目（国际科研计划联合研究项目）的主要成果如下：肺泡包虫病活动性病例与非活动性病例的区分：针对先前描述的表位Em18的抗体反应是肺泡包虫病活动性病变存在的良好标记。这项工作已经发表在两篇论文中：第一篇是伊藤和尚茨（1993），第二篇是伊藤，尚茨和威尔逊（1995）。肺泡棘球蚴病与囊性棘球蚴病等其他寄生虫病的鉴别：抗Em18抗体反应是肺泡棘球蚴病的良好标志物，而抗Em16抗体反应是囊性棘球蚴病的良好标志物。这项工作已经发表在几篇论文中：第一篇是伊藤等人（1993），第二篇是伊藤，王和刘（1993），第三篇是伊藤等人（1994），第四篇是温等人（1995）。另外三篇论文刚刚提交。新ELISA体系的建立：部分纯化的Em18和富集的Em16组分对活动性肺泡包虫病与囊性包虫病等其他寄生虫病的鉴别具有重要意义。这部作品正在准备出版。关于棘球蚴病和囊虫病的论文共发表或出版13篇，另有3篇已提交出版，另一篇正在准备在国际期刊上发表。还有其他一些关于实验性囊虫病的小论文。一些关于棘球蚴病和囊虫病的英文和日文综述论文也已出版或即将出版。这些成果包括未发表的合作成果，为今后从1995年开始为期三年的“棘球蚴病和囊虫病的分子免疫生物学”合作项目提供了丰富的信息和成果。

项目成果

Ito,Asano & Okamoto: "Protective antibodies against Taenia taeniaeformis in rats infected with eggs or injected with non-viable oncospheres or recombinant antigens of oncospheres" Parasite Immunology. 16. 463-468 (1994)

浅野伊藤

Ito,Schantz & Wilson: "Em18,a new serodiagnostic marker for differentiation of active and inactive cases of alveolar hydatid disease" American Journal of Tropical Medicine and Hygiene. 51. 41-44 (1995)

伊藤·尚茨

Ito,Ma,Itoh,Cho,Kong,Kang,Horii,Pang,Okamoto,Yamashita,Lightowlers,Wang & Liu: "Immunodiagnosis of alveolar echinococcosis versus cystic echinococcosis or ther parasitic diseases by ELISA using partially purified Em18 and Em16 enriched fraction compared w

伊藤、马、伊藤、町、孔、康、堀井、庞、冈本、山下、Lightowlers、王

Xu & Ito: "Diagnosis and classification of hepatic echinococcosis by ultrasonography" Southeast Journal of Tropical Medicine and public Health. (1995)

徐

Ito,Nakao,Kutsumi,Lightowlers,Itoh & Sato: "Serodiagnosis of alveolar hydatid disease by Western blotting" Transactions of the Royal Society of Tropical Medicine and Hygiene. 87. 170-172 (1993)

伊藤、中尾、久美、Lightowlers、伊藤