Basic research on development of experimental animal model for weak heat tolerance and bbehavioral thermoregulation

弱耐热及行为体温调节实验动物模型建立的基础研究

• 批准号: 06557007
• 负责人: KOSAKA Mitsuo
• 金额: $ 11.84万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06557007/
• 关键词: Pika; Ochotna; Thermal insulation; Thermal tolerance; hibernator; Telemetry; Body temperature; Skin hair; アフガン・ナキウサギ; クチグロ・ナキウサギ; テレメトリー; 乳酸値; 高体温; 血糖値; 日内リズム; 弱熱耐性; 行動性体温調節; 実験動物モデル; 寒冷ショック蛋白(CSP); 熱ショック蛋白(HSP); SDS-PAGE; Western Blo

(1) A Field Study of Telemetry-Recording of the Body Temperature in Wild Mongolian PikaThe pika inhabiting in cold zone or in high mountains is thought to be adapted to cold as well as high-altitude environment. We have reported pika's high body temperature (39.6ﾟC), high metabolism and poor heat loss ability such as poor lack of thermal salivation. In this study, we measured the body temperature of wild pikas (Ochotona daurica) with a telemetry device in their natural borrows in Mongolia. Two pikas captured at Under Dov were implanted with transmitters in the abdominal cavity under anesthesia, and were returned to the own habitat. The mean body temperatures of the pakas were 39.65ﾟC and and 39.96ﾟC,though the data were limited to a short period of less than one day. The present results in wild pikas support pika's high body temperature in our previous studies.(2) Anatomical observations and thermal tolerance in pika (Ochotona curzoniae)The heat insulations of chest and abdomen skin were inferior to back and waist. For pikas lying on their belly is a behavioral heat loss response. The high altitude adaptation of Pika in cold environment is due to heat conservation and heat production to be different from cold tolerance in hypothermia like as hibernator.

(1)野外遥测蒙古鼠兔体温的研究鼠兔生活在寒冷地区或高山地区，对寒冷和高海拔环境具有一定的适应性。鼠兔的体温高（39.6 ℃），代谢快，散热能力差，如热流涎不足。在本研究中，我们用遥测装置测量了蒙古国野生鼠兔（Ochotona daurica）的体温。在Under Dov捕获的两只鼠兔在麻醉下被植入腹腔内的发射器，并被送回自己的栖息地。帕卡的平均体温分别为39.65摄氏度和39.96摄氏度，尽管数据仅限于不到一天的短时间内。本研究结果支持了前人研究中鼠兔体温较高的观点。(2)鼠兔的解剖学观察与热耐受性胸、腹部皮肤的隔热性不如背部和腰部。对于鼠兔来说，趴着是一种行为上的热损失反应。高原鼠兔对寒冷环境的适应是由于其具有不同于冬眠动物低温耐寒性的储热和产热作用。

项目成果

Kosaka,M.: "A new approach to analysis of human sweating" Experientia. 52(2). 131-135 (1996)

Kosaka,M.：“分析人体出汗的新方法”Experientia。

Kosaka, M.: Body Temperature and Metabolism. Ed.by T.Nagasaka and A.S.Milton IPEC (International Press Editing Center Incorporation) Tokyo, 234 (1995)

Kosaka, M.：体温和新陈代谢。

小坂光男: "ナキウサギ(Pika)の弱熱耐性" 日本内分泌学会雑誌. 70(3). 89 (1994)

Mitsuo Kosaka：“鼠兔的耐热性较弱”，日本内分泌学会杂志 70(3) 89 (1994)。

Tsuchiya, K.: "Vasoconstriction induced by beta-adrenergic antagonist in the tail of chronic spinal rats." Tropical Medicine. 37(4). 175-183 (1995)

Tsuchiya, K.：“β-肾上腺素能拮抗剂在慢性脊髓大鼠尾部诱导血管收缩。”

Kosaka,M.: "In Integrative and cellula spects of autonomic function: Temperature and osmoregulation" Ed. by Pleschka, R.Gersberger John Libbey Eurotext Paris, 554 (1994)

Kosaka,M.：“在自主神经功能的综合和细胞方面：温度和渗透调节”Ed。