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Analysis of thermoregulatory and pyretic responses in heat-and cold-acclimation

热和冷驯化中的体温调节和发热反应分析

基本信息

批准号：
62480116
负责人：
KOSAKA Mitsuo
金额：
$ 3.97万
依托单位：
Institute of Tropical Medicine, Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1987
资助国家：
日本
起止时间：
1987 至 1988
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-62480116/
关键词：
Pika (Whistle rabbit)albino rabbit tropical subject sportsmen heat-and cold-acclimated rabbit pyrogenicity poor heat loss ability cerebral blood flow thermal sweating thyroid hormone heat-exercise cross adaptation 発汗測定体温調節機序暑熱-運

项目摘要

This investigation was designed to clarify the central and peripheral mechanism of thermal acclimation from the concept of hypothalamic and extra-hypothalamic thermosensitivity of CNS in human and animal.I. Pyrogenic and poor heat loss responses in pika (Whistle rabbit): Pika,s better heat conservation ability thought to be due to its higher metabolic rate. poor heat dissipation through the weak thermal panting and smaller ear surface area. Further, it was reported that pika is markedly senitive to narcotics, but it responds poorly to i.p. administration of LPS pyrogen. However, in the present study, it was clear that pika can elicit fever with i.v. LPS pyrogen but heat loss mechanism differs from that of albino rabbit, that is, the poor evaporative heat loss ability in pika is most probable due to smallness of the ear as a heat radiator and lack of thermal panting.II. Changes in cerabral blood flow (CBF) due to theraml acclimation; the change in CBF is closely associated with air temp … More erature as well as thermoregulatory parameters. Not only the less increase in CBF due to heating but also less decrease due to cooling was observed in the heat-acclimated rabbit compared to those of control rabbit, and similar results were obtained in the cold acclimated rabbit. The reduction of gain in thermoregulatory responses occurred during general heating and cooling as well as pyrogen administration in both heat- and cold- acclimated rabbits, so the reduced change in CBF of brain in the process of the thermal acclimation might cause habituation phenomenon of thermal responses to heat and cold stimulation.III. Analysis of heat-exercise cross adaptation in hot dry sauna; the heat acclimation procedure is capable of inducing heat acclimation to the sportsmen as well as the tropical subjects who may be closely related to inherent consititutional characteristic and his acquired heat tolerance, and the results of the spotsmen may be due to the enhanced ability of heat production and evaporative heat loss response owing to larger cross adaptability by co-operation of heat and exercise load.In this investigation, to clarity the effect of thyroid hormone on thermal sweating, thermal sweating in patients with hyperthyroidism and hypothyroidism was determined by using of capacitance hygrometer-sweat capture capsule method. However, further reseaches are necessary to clarity the effects of various hormones on thermal sweating and the action site of hormones on sweating mechanism. Less

本研究旨在从人和动物中枢神经系统的下丘脑和下丘脑外区热敏的概念来阐明热习服的中枢和外周机制。I.鼠兔的热原和散热反应差：鼠兔、S较好的保温能力被认为是由于其较高的代谢率所致。通过微弱的热喘息和较小的耳朵表面积散热较差。此外，据报道，鼠兔对毒品有明显的敏感性，但对ip反应很差。内毒素热原注射。然而，在目前的研究中，很明显，鼠兔可以通过静脉注射引起发热。…热原，但热损失机制不同于白兔，即鼠兔蒸发热损失能力较差，最可能是由于耳作为散热体较小，缺乏热喘息。II.热习服引起的脑血流量变化；脑血流量的变化与空气温度LBP密切相关更多的温度以及温度调节参数。与对照组相比，热习服组兔脑血流量增加较少，降温引起的脑血流量下降也较少，冷习服组也有类似的结果。热习服和冷习服过程中体温调节反应的增益均降低，热适应过程中热适应过程中脑血流量的变化可能引起热刺激和冷刺激的热反应习服现象。热习服程序能够诱导运动员和热带受试者的热习服，这可能与其固有的体质特征和获得性耐热性密切相关，而散热者的结果可能是由于热和运动负荷的共同作用使其产生热量的能力增强和蒸发热损失反应较大所致。为明确甲状腺激素对热汗的影响，采用电容湿度计-汗液捕获胶囊法测定了甲亢和甲减患者的热汗。然而，各种激素对热汗的影响以及激素在出汗机制中的作用部位还有待于进一步研究。较少