口腔癌におけるE-カドヘリンの発現と頸部リンパ節転移に関する研究

E-cadherin表达与口腔癌颈部淋巴结转移的研究

• 批准号: 06771931
• 负责人: 片岡 親男
• 金额: $ 0.51万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Encouragement of Young Scientists (A)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06771931/
• 关键词: 口腔扁平上皮癌; 細胞接着因子; 頚部リンパ節転移

近年,癌の浸潤,転移に関連する細胞接着因子の解析が進められている.われわれは,口腔扁平上皮癌患者一次症例27例を対象に,細胞接着分子の一つであるE-カドヘリンの発現様式と臨床病理組織学的所見ならびに頚部リンパ節転移との関係について免疫組織化学的に検討を行った.症例の性別内訳は男性18名,女性9名で,年齢は40歳から86歳,平均60.8歳であった.部位別では舌13例,口底6例,歯肉5例,頬粘膜2例,口峡咽頭1例であった.原発巣におけるE-カドヘリンの発現は腫瘍の発育深度によって異なり,stageI,IIの癌14例中,E-カドヘリンが減弱する例は5例(35.7%)と少なかったのに対し,発育先端部では9例(64.3%)で,さらにstageIII,IVの癌13例では浅〜中央部で減弱する例は6例(46.2%),発育先端部で12例(92.3%)と多くなり,病期が進行するに従って,E-カドヘリンの発現が減弱していた.分化度と発育先端部でのE-カドヘリン発現様式についてみると高分化型は14例中11例(78.6%),中等度分化型10例中7例(70%),低分化型3例中3例(100%)が減弱型を呈しており,特に分化度別との関連性は示唆されなかった.癌浸潤様式では1,2型8例中5例(62.5%),3型8例中6例(75%),4型10例中9例(90%)が発育先端部でE-カドヘリンが減弱しており,浸潤傾向が強い程,減弱型が多い傾向にあった.リンパ節転移群では12例中,原発巣発育先端部におけるE-カドヘリンの発現が減弱する例は10例(83.3%)で,2例はE-カドヘリンが依然として発現していた.このようなリンパ節転移群で非減弱型を示す症例についてはE-カドヘリンの機能異常が考えられ,E-カドヘリン関連のカテニンについて検討を進める必要がある.

In recent years, cancer cells have been immersed and transferred, followed by factor analysis. In 27 patients with oral flat epithelial carcinoma, there were 27 patients with oral flat epithelial carcinoma. the cells were followed by molecules that were detected by histopathology and histology of oral flat epithelioma. There were 18 males and 9 females, aged 40 to 86, with an average of 60.8. There were 13 cases of tongue, 6 cases of floor of mouth, 5 cases of flesh, 2 cases of mucous membrane and 1 case of mouth isthmus and pharynx. In 14 cases of stageI,II 's cancer, there were 5 cases (35.7%) of weak disease, 9 cases (64.3%) of early pregnancy, 13 cases of stageIII,IV cancer and 6 cases (46.2%) of superficial to central part. There were 12 cases (92.3%) with multiple ectopic pregnancy in the first part of the parturient. During the period of the disease, the first stage of the disease was repeated, and the weak symptoms were found in the stage of the disease. The degree of differentiation showed that there were 11 cases (78.6%) in 14 cases of advanced differentiation, 7 cases (70%) in 10 cases of moderately differentiated type, 3 cases (100%) in 3 cases of poorly differentiated type and 3 cases (100%) of low differentiated type. Of the 8 cases of cancer immersion type 1,2, 5 cases (62.5%), 6 cases (75%) of type 3, 9 cases (90%) of type 4, and 9 cases (90%) of type 4. Among the 12 cases, there were 10 cases (83.3%) with weak symptoms at the end of the original parturient, and 2 cases (83.3%). There is a case of non-weak symptoms of non-weak symptoms. There is a regular examination of the machine, and the necessary information is required.

项目成果

平塚博義: "術前化学療法により組織学に腫瘍が消失した口腔扁平上皮癌の臨床的組織学的検討" 日本口腔外科学会雑誌. 41(印刷中). (1995)

Hiroyoshi Hiratsuka：“由于术前化疗肿瘤组织学消失的口腔鳞状细胞癌的临床和组织学研究”日本口腔颌面外科杂志 41（出版中）。

片岡親男: "上唇に発生した多形性腺腫の6例" 日本口腔外科学会雑誌. 41. 39-42 (1995)

Chikao Kataoka：“上唇多形性腺​​瘤六例”日本口腔颌面外科杂志 41. 39-42 (1995)。