Assessment of the effectiveness of cancer therapy using PET.

使用 PET 评估癌症治疗的有效性。

• 批准号: 06670914
• 负责人: ISHIGAKI Takeo
• 金额: $ 1.34万
• 依托单位: Nagoya University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06670914/
• 关键词: PET; FDG; Fluorodeoxyglucose; Cancer; Radiation Therapy; Rectal Cancer; Lung Cancer; Cellularity; 治療効果判定; 治療効果予測; VX-2腫瘍; タリウムTlCl; FIBI; 化学療法

Morphologiacal imaging strategies such as plain radiography, X-ray CT,MRI and ultrasonography have been used for the evaluation of cancer treatment. The shape and diameter of tumor are compared before and after the treatment. Occasionally, we meet the cases of residual mass without viable tumor cells after the therapy. And there are many cases of early recurrent disease even if we could not identify the residual mass just after the treatment. Morphological approach has limited ability in the assessment of cancer therapy.FDG-PET has been accepted as a useful diagnostic tool in oncology. We applied FDG-PET study to the assessment of cancer treatment and compared with the morphological methods. Three consecutive FDG-PET studies before, in the middle of and after the radiation therapy were performed in fifteen patients with non-small cell lung carcinomas. FDG accumulation to the tumors were compared in three scans of each patient. Reduction of tumor size measured by plain radiography or CT … More after the treatment was correlated to FDG accumulation in most of the patients. However, there were some patients without agreement between morphological study and FDG-PET.These results suggest that FDG-PET has different information on the number of tumor cells and metabolic activity.Cellularity of the tumor and partial volume effect were studied, as a basic study of FDG uptake to tumor. Thirty-seven patients with suspected recurrent disease of rectal cancer were studied with FDG-PET.Correlation between the size of tumors and the FDG uptake was studied. FDG accumulation was compared to cellularity observed in histopathological examinations in several subjects. Positive correlation was found between the size and the uptake. This suggests that the size of the tumor should be taken into consideration for accurate estimation of FDG uptake. There was a correlation between cellularity and FDG uptake. When FDG-PET is used for the evaluation of therapy, the accumulation of FDG is considered to be dependent on the number of residual tumor cells.FDG-PET is able to provide new information, which could not be obtained by conventional morphological diagnostic imaging technique. FDG-PET is aeffective method for the assessment of cancer therapy. Less

形态学成像策略，如x线平片、x线CT、MRI和超声检查已被用于评估癌症治疗。比较治疗前后肿瘤的形状和直径。偶尔，我们会遇到治疗后残余肿块没有活的肿瘤细胞的情况。即使在治疗后我们不能确定残余肿块，也有许多早期复发的病例。形态学方法对肿瘤治疗的评价能力有限。FDG-PET已被公认为是一种有用的肿瘤诊断工具。我们将FDG-PET研究应用于肿瘤治疗的评价，并与形态学方法进行比较。对15例非小细胞肺癌患者进行放射治疗前、中、后连续3次FDG-PET检查。在每个患者的三次扫描中比较FDG在肿瘤中的积累。在大多数患者中，治疗后通过x线平片或CT测量的肿瘤大小减小与FDG积累有关。但也有部分患者形态学研究与FDG-PET不一致。这些结果表明，FDG-PET在肿瘤细胞数量和代谢活性方面具有不同的信息。研究FDG对肿瘤的细胞性和部分体积效应，作为FDG对肿瘤摄取的基础研究。对37例疑似直肠癌复发患者进行了FDG-PET检查。研究了肿瘤大小与FDG摄取的相关性。将FDG积累与组织病理学检查中观察到的细胞结构进行了比较。大小与摄取呈正相关。这表明在准确估计FDG摄取时应考虑肿瘤的大小。细胞结构与FDG摄取之间存在相关性。当FDG- pet用于评估治疗时，FDG的积累被认为依赖于残留肿瘤细胞的数量。FDG-PET能够提供传统形态学诊断成像技术无法获得的新信息。FDG-PET是评价肿瘤治疗效果的有效方法。少

项目成果

Ito K,Kato T,Ohta T,Tadokoro M,Yamada T,Ikeda M,Nishino M,Ishigaki T,Ito K,Gambhir S.: "Fluorine-18 fluoro-2-deoxyglucose positron emission tomography in recurrent rectal cancer : relation to tumour size and cellularity." European Journal of Nuclear Medic

Ito K，Kato T，Ohta T，Tadokoro M，Yamada T，Ikeda M，Nishino M，Ishigaki T，Ito K，Gambhir S.：“氟-18氟-2-脱氧葡萄糖正电子发射断层扫描在复发性直肠癌中的应用：与复发性直肠癌的关系

Ito K,Kato T,Ohta T,Tadokoro M,Yamada T,Ikeda M,Nishino M,Ishigaki T: "Fluorine-18 fluoro-2-deoxyglucose positron emission tomogtaphy in recurrent rectal concer : relation to tumor size and cellularity." European Journal of Naclear Medicine. 23. 1372-1377

Ito K、Kato T、Ohta T、Tadokoro M、Yamada T、Ikeda M、Nishino M、Ishigaki T：“复发性直肠癌中的氟 18 氟-2-脱氧葡萄糖正电子发射断层扫描：与肿瘤大小和细胞构成的关系。”

Ito k, Kato T, ohta T, Todolorc H, Yorada T, Ikeda, M Nielinop, Ishigaki T: "Fluorine-18 Fluoro-2-deoxyglucose positron emisslon tonography in recurrent rectal cancer: relation to tumour size and cellutarity." European Journal of Naclear Medicine. 23. 137

Ito k、Kato T、ohta T、Todolorc H、Yorada T、Ikeda、M Nielinop、Ishigaki T：“复发性直肠癌中的氟 18 氟 2-脱氧葡萄糖正电子发射断层扫描：与肿瘤大小和细胞性的关系。”

Kato T: "Fluorodeoxyglucose positron emission tomography in pancreatic cancer:an unsolved problem" European Journal of Nuclear Medicine. 22. 32-39 (1995)

Kato T：“胰腺癌中的氟脱氧葡萄糖正电子发射断层扫描：一个未解决的问题”欧洲核医学杂志。

伊藤健吾: "画像診断の親展開-MRI、PETが可能にした病態把握-悪性腫瘍" 最新医学. 49. 96-102 (1994)

Kengo Ito：“图像诊断的先进发展 - 通过 MRI 和 PET 使了解病理状况成为可能 - 恶性肿瘤” 现代医学 49. 96-102 (1994)。