Novel disinfection to combat antibiotic resistance

对抗抗生素耐药性的新型消毒方法

• 批准号: DP220101526
• 负责人: Prof Jianhua Guo
• 金额: $ 26.77万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-01-21 至 2025-01-20
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220101526
• 关键词: Novel; disinfection; combat; antibiotic; resistance

Control of antimicrobial resistance in water is critical. Disinfection in water and wastewater treatment plants is a vital barrier against antibiotic resistant bacteria (ARB); however, it is less effective in controlling- and may even facilitate the spread of antibiotic resistance genes (ARGs). This project aims to comprehensively investigate the effectiveness of widely-used disinfection processes in controlling ARB/ARGs, determine the underlying mechanisms, and identify optimal treatment conditions. This project also aims to develop a novel, cost-effective and environmentally friendly disinfection process for efficient ARGs destruction, thus significantly strengthening Australia’s capacity to prevent the spread of antibiotic resistance.

控制水中的抗菌素耐药性至关重要。水和废水处理厂的消毒是抵御抗生素耐药细菌（ARB）的重要屏障；然而，它在控制方面效果较差，甚至可能促进抗生素耐药基因（ARGs）的传播。本项目旨在全面研究广泛使用的消毒工艺在控制ARB/ARGs方面的有效性，确定其潜在机制，并确定最佳处理条件。该项目还旨在开发一种新颖、具有成本效益和环境友好的消毒工艺，以有效销毁ARGs，从而大大加强澳大利亚防止抗生素耐药性蔓延的能力。