加齢にともなう角層機能の変化と皮表および角質細胞間脂質の変化の関係

年龄相关的角质层功能变化与皮肤表面和角质细胞间脂质变化的关系

• 批准号: 06770631
• 负责人: 冨樫 きょう子
• 金额: $ 0.58万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Encouragement of Young Scientists (A)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06770631/
• 关键词: 保水機能; セラミド

加齢にともなう角層の保水機能と皮表および角質細胞間脂質の加齢による変化の関係を検討する目的で、20歳代の男性(若齢群)と60歳代の男性(高齢群)の下腿伸側を被験部位とし角層の保水機能を測定し、脂質の組成を分析した。若齢群では高齢群に比べて水分負荷前後のすべての値が統計的に有意に高値であった。皮表および角層間脂質の総重量は、若齢群がやや多い傾向にあるが、両者の間に統計的に有意差を認めなかった。脂質画分の重量は、若齢群が高齢群に比べてスクワレンとワックスエステルが統計的に有意に多く、高齢群は若齢群に比べてコレステロールサルフェイトとリン脂質が統計的に有意に多かった。皮脂由来の脂質と角質細胞層脂質に分けて比較すると、若齢群では皮脂由来の脂質が統計的に有意に高齢群より高値を示した。角質細胞間脂質は両者の間に統計的に有意な差を認めなかったさらに、セラミドについて各成分の割合を測定した。その結果、高齢群は若齢群に比べて統計的に有意にセラミド1の割合が少なく、セラミド4/5の割合が有意に多かった。若齢群と高齢群について角層の保水機能と皮表および角層間脂質の関係を検討した結果若齢群も高齢群も角層水分量と総脂質量および皮脂由来の脂質と表皮由来の脂質の重量の間に有意の相関を認めなかった。各々の脂質分画の検討においても、両群ともに有意の相関はなかった。角層水分量と各セラミド分画の割合の関係では若齢群も高齢群も単独では角層水分量と各セラミド分画の割合の間に統計的に有意の相関を認めなかったが、若齢群と高齢群を合わせた全例では、角層水分量とセラミドの割合の間に統計的に有意の正の相関を、角層水分量とセラミド4/5の割合の間に有意の負の相関を認めた。

With the addition of the water conservator, the water conservator can be used to measure the lower leg stretch of the lower leg of the 20-generation male (if the group), 60-generation male (high-aged group), 20-generation male (if the group), 60-generation male (high-aged group), 20-generation male (if the group), 60-generation male (high-aged group), 20-generation male (if the group), 60-generation male (high-aged group), 20-generation male (if the group), 60-generation male (high-aged group), 20-generation male (if the group), 60-generation male (high-aged group), 20-generation male (if the group), 60-generation male (high-aged group), 20-generation male (if the group), 60-generation male (high-aged group), 20-generation male (if If the temperature of the population is higher than that of the water content, the statistics of the population are intentionally higher than those of the population. The weight of fat between the corners of the leather table, and the intended difference between the statistics of the consumers and the consumers if the weight of the fat between the corners of the skin is different from the weight of the fat between the corners. Fat pictures are divided into weight, if the number of people in the group is higher than that in the population, and if the number of people in the group is more than that in the statistics of the statistics, the statistics of the group is more than that of the statistics. The origin of sebum is the origin of sebum, and if the sebum is derived from the origin of sebum, the statistics show that there is an intentional increase in fat. According to the statistics of the population, the composition of each component was measured. The results showed that if the population of the high population was less than that of the statistical data, it was less than that of the statistical data, and that of the high population was lower than that of the population. If the water conservator is capable of measuring the temperature of the water conservator in the high temperature group, the water content of the water in the high group, the amount of water, the amount of fat, the amount of sebum, the origin of the fat, the skin, the weight, the weight. Each piece of fat is divided into two parts, the group is interested in each other and the group is interested in each other. The angle water component is divided into two parts, the angle water component is divided into two parts, the angle water component is divided into two parts, the angle water component is divided into two parts, the angle water weight is divided into two parts, the angle water content is divided into two parts, the angle water content is divided into two parts, the angle water content is divided into two parts, the angle water content is divided into two parts, the angle water content is divided into two parts, the angle water content is divided into two parts, and the statistics are calculated in terms of the statistics of the statistics. The amount of water in the corner, the amount of water, the amount of water.