Anthropological and genetic studies on uveitis in Mongoloids

1997财政年度在叙利亚、约旦、蒙古和葡萄牙对蒙古族人群中常见的顽固性葡萄膜炎综合征进行了人类学和分子遗传学研究。在叙利亚和约旦，白塞病患者较多，眼科和风湿科的患者大多为白塞病患者，与日本非常相似。然而，Vogt-Koyanagi-Harada病在这些国家很少见。在叙利亚，葡萄膜炎调查诊所还没有建立，我们建议他们如何为我们未来的合作研究建立这个诊所。然而，在约旦，已经建立了一家治疗白塞病的专科诊所，我们可以看到50多例典型的白塞病病例。我们还可以从这些患者身上采集血液样本进行HLA-DNA配型。我们实验室正在对这些样本进行分子遗传学分析。在蒙古国，有许多I-…患者葡萄膜炎综合征较多，白塞病或Vogt-Koyanagi-Harada病为典型病例。另一方面，蒙古没有患者被诊断为结节病。正如预期的那样，蒙古葡萄膜炎的临床表现与日本大体相似。葡萄牙地处所谓的丝绸之路的西端，与日本等地中海国家相似，也有很多白塞病患者。然而，Vogt-Koyanagi-Harada病或结节病并不像日本那样常见。在下一项研究中，将对葡萄牙白塞病患者进行人类白细胞抗原5101的关联研究。我们实验室今年也对以前从沙特阿拉伯或希腊采集的血液样本进行了人类白细胞抗原-DNA分型，并在这些患者中发现了与日本患者相同的人类白细胞抗原I类关联。从这些结果可以得出结论，在蒙古族人群中常见的某些类型的顽固性葡萄膜炎也与丝绸之路一起出现，这些葡萄膜炎可能是随着古老的游牧民族的迁徙而传播的。较少

Anthropological and molecular genetic studies on intractable uveitis syndromes which are frequently seen in the Mongoloid population were performed in Syria, Jordan, Mongol and Portugal in the fiscal year of 1997.In Syria and Jordan, there were many patients with Behcet's disease, and most of the patients in the Ophthalmology Department as well as the Rheumatology Department were those with Behcet's disease, quite similar to Japan. However, Vogt-Koyanagi-Harada's disease was rarely seen in these countries. In Syria, uveitis survey clinic was not yet established, and we advised them how to establish this for our future cooperative studies. In Jordan, however, a speciality clinic for Behcet's disease was already established, and we could see more than 50 typical cases of Behcet's disease. We could also get blood samples from these patients for the HLA-DNA typing. Molecular genetic analyzes on these samples are now in progress in our laboratory.In Mongolia, there were many patients with i … More ntractable uveitis syndromes, and typical cases with Behcet's disease or Vogt-Koyanagi-Harada's disease were seen. On the other hand, no patients were diagnosed as sarcoidosis in Mongolia. Clinical festures of uveitis in Mongolia was generally similar to Japan, as had been expected. In this investigation, we could establish a scientific basis for future cooperative studies.Portugal is located in the west end of the so-called Silk-Route, and similar to Japan and other Mediterranean countries, there were many Portuguese patients with Behcet's disease. However, Vogt-Koyanagi-Harada's disease or sarcoidosis was not as frequent as in Japan. In the next study, association of HLA-B^<**>5101 is to be studied in Portuguese patients with Behcet's disease.Blood samples collected before from Saudi Arabia or Greece were also HLA-DNA typed in our laboratory this year, and the same HLA class I association with Japanese patients was found in these patients.We can conclude from these results that certain types of intractable uveitis frequently seen in the Mongoloid population are also seen along with the Silk-Route, and these uveitis may have been spread along with the migration of the old Nomadic Tibes. Less