Anthropological and genetic studies on uveitis in Mongoloids

1997年财政年度，在叙利亚、约旦、蒙古和葡萄牙对蒙古人种中常见的顽固性葡萄膜炎综合征进行了人类学和分子遗传学研究。在叙利亚和约旦，白塞病患者较多，眼科和风湿科的患者多为白塞病患者，与日本非常相似。然而，Vogt-Koyanagi-Harada病在这些国家很少见。在叙利亚，葡萄膜炎调查诊所尚未建立，我们建议他们如何建立这个诊所，以便我们未来的合作研究。然而，在约旦，已经建立了白塞氏病的专科诊所，我们可以看到50多例典型的白塞氏病。我们也可以从这些病人身上提取血液样本进行HLA-DNA分型。我们实验室正在对这些样品进行分子遗传学分析。在蒙古，有较多的难治性葡萄膜炎综合征，有典型的白塞病或Vogt-Koyanagi-Harada病。另一方面，蒙古没有诊断为结节病的患者。正如预期的那样，蒙古葡萄膜炎的临床特征与日本大致相似。通过本次调查，为今后的合作研究奠定科学基础。葡萄牙位于所谓“丝绸之路”的西端，与日本等地中海国家相似，葡萄牙也有很多白塞病患者。然而，Vogt-Koyanagi-Harada病或结节病并不像日本那么常见。在接下来的研究中，将在葡萄牙白塞病患者中研究HLA-B^<**>5101的相关性。我们今年在沙特阿拉伯和希腊采集的血样也进行了HLA- dna分型，在这些患者中发现了与日本患者相同的HLA- I类关联。我们可以从这些结果中得出结论，蒙古人种中常见的某些类型的顽固性葡萄膜炎也伴随着丝绸之路出现，这些葡萄膜炎可能是随着古老的游牧西藏人的迁移而传播的。少

Anthropological and molecular genetic studies on intractable uveitis syndromes which are frequently seen in the Mongoloid population were performed in Syria, Jordan, Mongol and Portugal in the fiscal year of 1997.In Syria and Jordan, there were many patients with Behcet's disease, and most of the patients in the Ophthalmology Department as well as the Rheumatology Department were those with Behcet's disease, quite similar to Japan. However, Vogt-Koyanagi-Harada's disease was rarely seen in these countries. In Syria, uveitis survey clinic was not yet established, and we advised them how to establish this for our future cooperative studies. In Jordan, however, a speciality clinic for Behcet's disease was already established, and we could see more than 50 typical cases of Behcet's disease. We could also get blood samples from these patients for the HLA-DNA typing. Molecular genetic analyzes on these samples are now in progress in our laboratory.In Mongolia, there were many patients with i … More ntractable uveitis syndromes, and typical cases with Behcet's disease or Vogt-Koyanagi-Harada's disease were seen. On the other hand, no patients were diagnosed as sarcoidosis in Mongolia. Clinical festures of uveitis in Mongolia was generally similar to Japan, as had been expected. In this investigation, we could establish a scientific basis for future cooperative studies.Portugal is located in the west end of the so-called Silk-Route, and similar to Japan and other Mediterranean countries, there were many Portuguese patients with Behcet's disease. However, Vogt-Koyanagi-Harada's disease or sarcoidosis was not as frequent as in Japan. In the next study, association of HLA-B^<**>5101 is to be studied in Portuguese patients with Behcet's disease.Blood samples collected before from Saudi Arabia or Greece were also HLA-DNA typed in our laboratory this year, and the same HLA class I association with Japanese patients was found in these patients.We can conclude from these results that certain types of intractable uveitis frequently seen in the Mongoloid population are also seen along with the Silk-Route, and these uveitis may have been spread along with the migration of the old Nomadic Tibes. Less