Immuno-genetics on Mongoloid in Pan-Pacific and Northland Areas

为了有助于建立有关蒙古人种在世界范围内传播的全面信息，我们研究了近20年来蒙古人种中肿瘤病毒的民族流行病学特征和免疫遗传学特征。为了分析北方地区蒙古族人群中HTLV-1的地理和种族分布以及人类白细胞抗原(HL A)和脂肪代谢产物的遗传多态性，本研究以加拿大北部和丹麦东格陵兰的200名因纽特人为研究对象。我们预计在冬季(2月1月)进行实地工作，届时土著人民将根据上述目的在一个地方定居。2006年，我们计划与温哥华大学合作，对加拿大北部育空地区的因纽特人进行实地调查，但我们最终未能从不列颠哥伦比亚省政府当局获得采集土著人民血液样本的官方许可。相反，我们调查了爱知县600名日本人的人类白细胞抗原亚型(DR、DP、DQ)频率，以比较世界范围内蒙古族人群的特征分布。2007年，我们把重点放在丹麦东格陵兰岛的因纽特人身上，并进行了一次实地工作，从Ittoqqortoormiit的100-200人身上采集了血液样本，但由于格陵兰当局的命令，我们不得不放弃采集血液样本。如今，我们正在与丹麦研究人员谈判合作事宜，这些研究人员在过去几年里从同一地区的因纽特人身上采集了血液样本。另一方面，我们在日研研究所生物资源中心建立了近20年来收集的全球蒙古族淋巴细胞库(Sonoda-Tajima Collection)，以便对这些有价值的材料进行多用途的利用。我们收集了关于HTLV-I在世界各地蒙古人中的分布及其免疫遗传学特征的全面信息。

To contribute to the establishment of comprehensive information on worldwide Mongoloid dispersal, we have studied ethnoepidemiologic features of tumour viruses and immuno-genetic characteristics among Mongoloids during the last twenty years. To analyze geographic and ethnic distribution of HTLV-1and genetic polymorphism patterns of human leucocyte antigen (HLA) and fat metabolites among Mongoloid people in Northland areas in the present study, we focused on 200 Inuit people in North Canada and East Greenland (Denmark). We projected field works in winter season (January of February) when indigenous people settle down in one place according to the mentioned above purposes. In 2006 we planned a field work on Inuit people in Yukon area, North Canada in collaboration with University of Vancouver, but we finally could not get official permission of collecting blood samples from indigenous people from the authority of British Columbian Government. Instead of it, we invested HLA subtypes (DR, DP, DQ) frequency among 600 Japanese people in Aichi Prefecture to compare characteristic distribution among worldwide Mongoloids people. In 2007 we focused on Inuit people in East Greenland, Denmark and conducted a field work to collect blood samples from 100-200 people in Ittoqqortoormiit, but we had to obliged giving up collecting blood samples because of order to stop from the Greenland authority. Nowadays we are negotiating collaboration with Danish researchers who have collected blood samples from Inuit people in the same area during the last several years. On the other hand we have established lymphocytes bank (Sonoda-Tajima Collection) of worldwide Mongoloid people which we collected during the last 20 years linked with the present study, at the Bio-resource Center, RIKEN Institute for multipurpose usage of those valuable materials. We put together comprehensive information on worldwide distribution of HTLV-I among Mongoloids and their immuno-genetic characteristics.