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Anthhropological and genetic studies on ocular inflammatory diseases in Mongoloids

蒙古人种眼部炎症疾病的人类学和遗传学研究

基本信息

批准号：
10041203
负责人：
OHNO Shigeaki
金额：
$ 6.85万
依托单位：
Yokohama City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A).
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

项目摘要

It is well known that certain intractable inflammatory ocular diseases occur only in Mongoloid population. We have been studying the epidemiology, clinical feature, medical anthropology, and molecular genetics in mainly Vogt-Koyanagi-Harada disease and Behcet's disease.It was revealed that Vogt-Koyanagi-Harada disease was found in East Asian countries, Central Asian countries, North America and South America. In contrast, in Caucasians, this disease was rarely found. Vogt-Koyanagi-Harada disease was frequently seen in Australian Aborigini people, and possibly, in Papua New Guinean population. Since this disease is strongly associated with HLA-DRB1ィイD1*ィエD104 in East Asian patients, it is important to further study if the same HLA association is found in other populations.In Behcet's disease, no patients were found in East Asian countries. This disease was mainly found along the Silk Road, such as Korea, China, Iran, Turkey, and Morocco. In these countries, the number of new cases is still increasing and further epidemiological studies are needed to investigate the possible cause for this. In 1998's investigation we saw patients with Behcet's disease in Mongolia. This is the first report of the world. We have finished analyzing the molecular genetics of Greek patients with Behcet's disease. The frequency of HLA-BィイD1*ィエD15101 was 81.1 %, significantly higher than the healthy normal Greek controls. MICA-A6, one of the microsatellite alleles near the HLA region, was also significantly associated with this disease. It was interesting to find the same HLA association between Japanese and Greek patients with Behcet's disease.We have successfully gotten the blood samples from typical patients with Behcet's disease in Iran and Turkey. And it is expected that we could also get the samples from Morocco. Further HLA-DNA analyses will be performed in the near future.

众所周知，某些顽固性炎症性眼病只发生在蒙古族人群中。我们对Vogt-Koyanagi-Harada病和白塞病的流行病学、临床特征、医学人类学和分子遗传学进行了研究，发现Vogt-Koyanagi-Harada病在东亚国家、中亚国家、北美和南美洲都有发现。相比之下，在高加索人中，这种疾病很少发现。Vogt-Koyanagi-Harada病常见于澳大利亚原住民，也可能见于巴布亚新几内亚人。由于在东亚患者中，白塞病与HLADRB1D1D104有很强的相关性，因此在其他人群中是否也发现了同样的ィイD1D104关联，值得进一步研究。在白塞病患者中，在东亚国家未发现患者。该病主要分布在丝绸之路沿线，如朝鲜、中国、伊朗、土耳其和摩洛哥。在这些国家，新病例的数量仍在增加，需要进一步的流行病学研究来调查可能的原因。在1998年S的调查中，我们在蒙古发现了白塞病患者。这是世界上第一份报告。我们已经完成了希腊白塞病患者的分子遗传学分析。HLABィイD1*ィエD15101等位基因频率为81.1%，显著高于希腊健康对照组。MICA-A6是一种靠近人类白细胞抗原区域的微卫星等位基因，也与本病有显著关联。有趣的是，在日本和希腊的白塞病患者之间发现了相同的人类白细胞抗原相关性。我们已经成功地从伊朗和土耳其的典型白塞病患者身上获得了血液样本。预计我们也可以从摩洛哥拿到样品。进一步的人类白细胞抗原-DNA分析将在不久的将来进行。