Investigation of disease susceptibility genes associated with intractable intraocular inflammation with racial differences and development of new antioxidant therapy
Investigation of disease susceptibility genes associated with intractable intraocular inflammation with racial differences and development of new antioxidant therapy
批准号:
19406028
负责人:
OHNO Shigeaki
金额:
$10.82万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
In GWAS studies in Behcet disease, 2 new genes and HLA-B*510101 were found. In Vogt-Koyanagi-Harada disease, HLA-DRB1*0405 and several genetic associations were also found. Virological studies revealed 2 new human adenoviruses (HAdV 53 and 54). One of the carotenoids, astaxanthin showed significant increase of choroidal blood flow. DHMEQ, a new NF-κB blocker also showed significant suppression of experimental uveoretinitis.
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Low prevalence of juvenile-onset Behcet's diease with uveitis in east/south Asian people
东亚/南亚人群中青少年发病的白塞氏病伴葡萄膜炎的患病率较低
DOI:
--
发表时间:
2009
期刊:
Br J Ophthalmol VOL. 93
影响因子:
--
作者:
[Kitaichi N, Miyazaki A, Stanford MR, Iwata D, Chams H, Ohno S]
通讯作者:
Ohno S
炎症性眼疾患の診療 若年性関節リウマチに伴う前部内眼炎
治疗炎症性眼病与幼年类风湿性关节炎相关的前眼内炎
DOI:
--
发表时间:
2007
期刊:
臨床眼科 61
影响因子:
--
作者:
[Deu SK, Okitsu S, Ushijima H., Kase S, Dey SK, Kase S, Chanit W, Kitamura M, Dey SK, Matsuda A, Dey SK, Yatsu K, Trinh QD, Goto H, Khamrin P, Kitaichi, Khamrin P, Sfikakis PP, 北村瑞, Pham NTK, 北市伸義]
通讯作者:
北市伸義
炎症性眼疾患の診療 間質性腎炎ぶどう膜炎症候群
治疗炎症性眼病 间质性肾炎 葡萄膜炎综合征
DOI:
--
发表时间:
2007
期刊:
臨床眼科 61
影响因子:
--
作者:
[Deu SK, Okitsu S, Ushijima H., Kase S, Dey SK, Kase S, Chanit W, Kitamura M, Dey SK, Matsuda A, Dey SK, Yatsu K, Trinh QD, Goto H, Khamrin P, Kitaichi, Khamrin P, Sfikakis PP, 北村瑞, Pham NTK, 北市伸義, 清水優子, 小竹聡, 石田眞一, 牛島廣治, 合田千穂]
通讯作者:
合田千穂
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Ohno S, Namba K, Kitaichi N, Ishida S.]
通讯作者:
Ishida S.
Early systemic corticosteroid therapy may reduce ocular complications in Vogt-Koyanagi-Harada disease
早期全身皮质类固醇治疗可减少 Vogt-Koyanagi-Harada 病的眼部并发症
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Ohno S, Hirose S, Kitaichi N.]
通讯作者:
Kitaichi N.
共 88 条
Comprhensive examination for serum autoantigens in endogenous uveitis patients
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批准号:23592602
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.41万
-
财政年份:2011
-
负责人:OHNO Shigeaki
-
依托单位:
Molecular genetics and molecular epidemiology of intractable intraocular inflammation frequently found in Mongoloids for prevention of blindness.
-
批准号:16406032
-
项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.45万
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财政年份:2004
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负责人:OHNO Shigeaki
-
依托单位:
New development in molecular genetic and molecular pharmacological studies on intractable intraocular inflammation.
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批准号:16209051
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$32.2万
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财政年份:2004
-
负责人:OHNO Shigeaki
-
依托单位:
Molecule genetic and molecule immunologic investigations on the mechanisms of viral ocular inflammation
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批准号:14370550
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.34万
-
财政年份:2002
-
负责人:OHNO Shigeaki
-
依托单位:
ANTHROPOLOGICAL AND MOLECULAR GENETIC STUDIES ON THE EPIDEMIOLOGY OF INTRACTABLE OCULAR DISEASES
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批准号:12576022
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.79万
-
财政年份:2000
-
负责人:OHNO Shigeaki
-
依托单位:
Studies on molecular genetic mechanism of intractable immune-mediated inflammatory diseases of the eye by genomic analyses
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批准号:12307038
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$26.76万
-
财政年份:2000
-
负责人:OHNO Shigeaki
-
依托单位:
Anthhropological and genetic studies on ocular inflammatory diseases in Mongoloids
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批准号:10041203
-
项目类别:Grant-in-Aid for Scientific Research (A).
-
资助金额:$6.85万
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财政年份:1998
-
负责人:OHNO Shigeaki
-
依托单位:
Molecular mechanism of intractable ocular diseases
-
批准号:10671650
-
项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
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财政年份:1998
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负责人:OHNO Shigeaki
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依托单位:
Molecular genetic studies on Behcet's disease
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批准号:08457466
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.74万
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财政年份:1996
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负责人:OHNO Shigeaki
-
依托单位:
Anthropological and genetic studies on uveitis in Mongoloids
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批准号:07041166
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$9.92万
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财政年份:1995
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负责人:OHNO Shigeaki
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依托单位:
MOLECULAR IMMUNOLOGICAL STUDIES ON ITRACTABLE UVEITIS FREQUENTLY SEEN IN JAPAN.
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批准号:05671472
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.41万
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财政年份:1993
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负责人:OHNO Shigeaki
-
依托单位:
Anthropological and genetic studies on uveitis in Mongoloids
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批准号:05041117
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$5.12万
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财政年份:1993
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负责人:OHNO Shigeaki
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依托单位:
Immunological studies on the mechanism and treatment of inflammatory ocular diseases
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批准号:61570837
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1986
-
负责人:OHNO Shigeaki
-
依托单位:
海外基金