Comprhensive examination for serum autoantigens in endogenous uveitis patients

内源性葡萄膜炎患者血清自身抗原的综合检查

• 批准号: 23592602
• 负责人: OHNO Shigeaki
• 金额: $ 3.41万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592602/
• 关键词: ぶどう膜炎; ベーチェット病; 原田病; 自己抗体; 内因性ぶどう膜炎; 難治性内因性ぶどう膜炎; 網羅的解析; バイオインフォマティクス解析; バイオマーカー

In this study, serum autoantigens were examined comprhensively in the patients with endogenous uveitis by using our novel detection system.Serum samples were divided into 3 pooled groups.Among Vogt-Koyanagi-Harada disease patients, 10 kinds of proteins were elevated more than one-and-a-half levels compared with healthy volunteers in sera. Behcet's disease patients also showed that 6 kinds of serum proteins were increased levels by half compared with those of healthy subjects.We further demonstarted that 3 of these elevated proteins were common to Vogt-Koyanagi-Harada disease and Behcet disease.

本研究应用新的检测系统对内源性葡萄膜炎患者血清中的自身抗原进行了全面检测，将血清样本分为3组，发现Vogt-Koyanagi-Harada病患者血清中有10种蛋白质的含量比健康志愿者高1.5个水平以上。白塞病患者血清中有6种蛋白质水平较正常人升高一半，其中3种蛋白质水平升高与Vogt-Koyanagi-Harada病和白塞病相同。

项目成果

Genome variability of human adenovirus type 8 causing epidemic keratoconjunctivitis during 1986-2003 in Japan

• 发表时间: 2011-11
• 期刊: Molecular Vision
• 影响因子: 2.2
• 作者: X. Jin;K. Aoki;N. Kitaichi;T. Ariga;S. Ishida;S. Ohno

Ocular lesions in Behcet's disease

白塞氏病的眼部病变

• 发表时间: 2012
• 作者: Goto S;Fujinami K;Akahori M;Iwata T;Noda T;Tsunoda K et al.;Ohno S
• 通讯作者: Ohno S

周辺虹彩前癒着を伴うぶどう膜炎に続発した緑内障に対するsuture-trabeculotomyの成績

缝合小梁切开术治疗葡萄膜炎继发青光眼伴周围前粘连的结果

• 发表时间: 2013
• 作者: 大口剛司;新明康弘;新田卓也;山本麻梨亜;南場研一;大野重昭;陳 進輝;石田 晋
• 通讯作者: 石田 晋

Identification of contamination in the American Type Culture Collection stock of human adenovirus type 8 by whole genome sequencing.

通过全基因组测序鉴定美国典型培养物保藏中心库存中人类 8 型腺病毒的污染。

• DOI: 10.1128/jvi.02875-12
• 发表时间: 2013
• 期刊: J Virol
• 影响因子: 5.4
• 作者: Yamane S;Lee A;Hanaoka N;Gonzalez G;Kaneko H;Ishida S;Kitaichi N;Ohno S;Koyanagi K;Aoki K;Fujimoto T;Yawata N;Watanabe H.
• 通讯作者: Watanabe H.

Corticosteroid therapy of uveitis and intraocular inflammation

葡萄膜炎和眼内炎症的皮质类固醇治疗

• 发表时间: 2011
• 作者: Ohno S;Namba K
• 通讯作者: Namba K