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The role of water metabolism on the environmental adaptation

水代谢对环境适应的作用

基本信息

批准号：
07307002
负责人：
MORIMOTO Taketoshi
金额：
$ 4.86万
依托单位：
Kyoto Prefectural University of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07307002/
关键词：
Water metabolism Environmental adaptation Drinking Central control of water balance Comparative physiology Water balance and body temperature Water balance and circulation feedforward control 飲水行動水代謝の比較生理学

项目摘要

Adaptive mechanisms to various environments were studied in relationship with water balance. The scientist gathered for this projects were experts in this field, and deal with receptor mechanisms, volume and osmolar receptors, thirst and drinking behavior, sympathetic control of renal function, central mechanisms of water balance, the relationship between water balance and regulations of body temperature and circulation, and comparative aspects of water metabolism. These scientists gather twice during the term of this projects, and exchanged their recent progress of their research and ideas, and tried to obtain the integration of individual research.New findings reported during this projects are as follows : Modification of osmosensitivity of AVP secretory cells and AV3V cells by estrogen (Akaish & Honma) , the role of liver Na-receptor in the feedforward control of Na balance (Hosomi, Morita) , the role of IL-1 in the control of drinking behavior, cardio-vascular and kidney function (Kannan) , analysis of body fluid shift with continuous determination of blood density and serum electrolytes in response to headout water immersion (Shiraki) , comparative analysis of ANP-family (CNP,BNP,VNP) and its significance in evolution (Takei) , central neuronal network for the control of AVP secretion (Negoro) , cell mechanisms of osmoreception by PVN and SON neurons (Ysamashita) , cerebrospinal osmolality and control of cutaneous circulation(Nose), and the effects of body fluid volume and osmolality on the control of circulation and body temperature regulation (Morimoto).At the meeting held on November 29-30, synthesis of the results from member investigators were discussed, and each participant agreed with the necessity of this kind of cooperation in future.

从水分平衡的角度研究了植物对各种环境的适应机制。为这个项目聚集的科学家是这一领域的专家，并处理受体机制，体积和渗透压受体，口渴和饮水行为，肾功能的交感神经控制，水平衡的中枢机制，水平衡与体温和循环调节之间的关系，以及水代谢的比较方面。这些科学家在本项目期间两次聚会，交流他们的研究和想法的最新进展，并试图获得个人研究的整合。本项目期间报告的新发现如下：雌激素对AVP分泌细胞和AV 3V细胞的细胞周期敏感性的影响（Akaish & Honma），肝脏Na受体在Na平衡前馈控制中的作用（Hosomi，Morita），IL-1在控制饮酒行为、心血管和肾功能中的作用（Kannan），通过连续测定血液密度和血清电解质分析头外水浸（Shiraki）引起的体液转移，ANP家族的比较分析（CNP，BNP，VNP）及其在进化中的意义（Takei），控制AVP分泌的中枢神经元网络（Negoro），PVN和SON神经元的细胞机制（Ysamashita）、脑脊液渗透压和皮肤循环控制（Nose），以及体液容量和渗透压对循环控制和体温调节的影响（森本）在11月29日至30日举行的会议上，讨论了成员研究者的成果汇总，与会者一致认为今后有必要开展这种合作。