Study related to the exercise and the non-specific immunity in middleaged and elder

中老年人运动与非特异性免疫的相关研究

• 批准号: 07458019
• 负责人: SHINDO Munehiro
• 金额: $ 1.47万
• 依托单位: Fukuoka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07458019/
• 关键词: Elderly; Habitual exercise; Mild aerobic exercise; Training; Non-specific Immunity; LT強度; 非特異的免疫; 好中球; NK細胞; 中高年者; 免疫; 顆粒球; 補体; サイトカイン; 免疫能; 活性酸素; 運動; 非特異的免疫能

The effects of acute and habituation of exercises on non-specific immunity in aged were examined to quantify the opilimal exercise for improving the immunity. The results indicates that : 1 - the acute-mild-aerobic exercise for more than 60 min increases oxidative burst in aged who are not performing a regular exercise ; 2- the regular exercise at 50% VO2max intensity for 60 min per day improves the oxidative burst in aged (resluts from the cross sectional study) : 3- five and more weeks of optimal exercise training is necessary for improving aerobic work capacity, and 1O and more weeks for enhancing nonspecific immunity, especially, phagocytosis of neutrophils in aged.The effects of habitual, moderate exercises (jogging, cycling, tennis, etc.) on the distribution of T-/B-lymphocytes (T-/B-cells) and NK cells were tested. Lymphocyte counts and T-cell/B-cell ratio were not different among the three age groups : young (20-39yr), middle-aged (4O-59yr) and elderly (6Oyr*). In the component … More s on innate immunity, the concentration on NK-cell was not altered with age, not will, habitual exercise, but the oxidative burst and phagocytosis of neutrophils showed a relative increase in the elderly exercisers as compared with the elderly sedentary subjects.The relationship between daily psycological stress estimated by the STAI score and immunocompetence in non exercisers and moderate exercisers who were regularly practicing moderate exercise, such as jogging, cycling, tennis or swimming were investigated. Male volunteers were separated into three age groups : young (20-39yr), middle-aged (40-59yr) and elderly (60yr*), and the generation differences were also examined. The results indicate that the moderate exercise may mitigate the stress level, leading to a better immunological condition of the individual. The higher level of CD8+killer/suppressor T-cells in the stressful controls may be due to an increase of stress hormones and may suppress other effector cell functions, especially in the younger generations. Less

本研究旨在探讨急性运动和习惯性运动对老年人非特异性免疫功能的影响，以量化提高免疫功能的适宜运动。结果表明：1 -超过60分钟的急性-轻度-有氧运动增加了不进行常规运动的老年人的氧化爆发; 2-每天以50%VO2max强度进行60分钟的常规运动改善了老年人的氧化爆发。（横截面研究的结果）：3- 5周及以上的最佳运动训练对提高有氧工作能力是必要的，10周及以上的最佳运动训练对增强非特异性免疫力是必要的，特别是，老年人中性粒细胞的吞噬作用。习惯性的、适度的运动（慢跑、骑自行车、网球等）的影响对T-/B-淋巴细胞（T-/B-细胞）和NK细胞的分布进行了测试。淋巴细胞计数和T细胞/B细胞比值在青年（20- 39岁）、中年（40 - 59岁）和老年（60岁）三个年龄组之间没有差异。在部件中 ...更多信息 在天然免疫方面，老年运动者的NK细胞浓度不随年龄的增长而变化，而中性粒细胞的氧化爆发和吞噬功能则相对增加，以STAI评分评估的日常心理应激与经常进行中等强度运动的非运动者和中等强度运动者的免疫功能之间的关系，如慢跑、骑自行车、打网球或游泳。将男性志愿者分为三个年龄组：青年（20- 39岁）、中年（40- 59岁）和老年（60岁 *），并检查了代间差异。结果表明，适度的运动可以缓解应激水平，从而使个体的免疫状况得到改善。在应激对照中较高水平的CD 8+杀伤/抑制T细胞可能是由于应激激素的增加，并且可能抑制其他效应细胞功能，特别是在年轻一代中。少

项目成果

永山在明・黒岩中他: "中高齢者の易感染性、高腫瘍発生率に対する予防的対策" 全国乳酸菌研究会. 540-545 (1997)

Zaiaki Nagayama、Naka Kuroiwa 等：“中老年人感染易感性和高肿瘤发病率的预防措施”国家乳酸菌研究组 540-545 (1997)。

木下藤寿・進藤宗洋他: "中高年者の免疫機能と運動" 体育の科学. 46・2. 98-103 (1996)

Fujitoshi Kinoshita、Munehiro Shindo 等：“中老年人的免疫功能和运动”《体育科学》46・2（1996）。