PHOTODYNAMIC TREATMENT OF BENIGN UTERINE DISEASE

良性子宫疾病的光动力治疗

• 批准号: 6182538
• 负责人: Bruce J. Tromberg
• 金额: $ 18.3万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-03 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6182538
• 关键词: biomedical equipment development; clinical biomedical equipment; clinical research; clinical trial phase I; drug screening /evaluation; endometrium; female; fiber optics; histology; human subject; human therapy evaluation; laboratory rat; laser therapy; light microscopy; pharmacokinetics; photobiology; photosensitizing agents; phototherapy; radiation therapy; scanning electron microscopy; topical drug application; uterus disorder; women's health

DESCRIPTION: The long-term goal of the proposed work is to develop a new, minimally-invasive treatment of benign uterine disease based on Photodynamic Therapy (PDT). Eventually, uterine PDT may have a significant impact on women's health care and its associated costs because it will provide an inexpensive, outpatient alternative to conventional surgical and medical techniques for treating dysfunctional uterine bleeding (DUB) and improving adenomyosis (AM)-related symptoms. During the past six years we have completed a number of animal, human and modeling studies that have helped us understand the complexity inherent to achieving irreversible endometrial ablation (EA) during PDT. We now propose a major new effort which builds on this foundation and further characterizes how light and drug dosimetry parameters affect clinical outcome. Specific aims include: 1) constructing, characterizing and optimizing performance of a novel, minimally-invasive intrauterine light probe (IULP); 2) completing Phase I/II and beginning Phase III human clinical trials with ALA; 3) testing a limited number of new sensitizers in animal models; and 4) evaluating pharmacokinetics, safety and efficacy of a limited number of new compounds in humans.

描述：拟议工作的长期目标是开发一种新的，

项目成果

Intrauterine light probe for photodynamic ablation therapy.

用于光动力消融治疗的宫内光探头。

• 发表时间: 1999
• 期刊: Obstetrics and gynecology
• 影响因子: 7.2
• 作者: Tadir,Y;Hornung,R;Pham,TH;Tromberg,BJ
• 通讯作者: Tromberg,BJ