课题基金 / 基金详情

PHOTODYNAMIC TREATMENT OF BENIGN UTERINE DISEASE

PHOTODYNAMIC TREATMENT OF BENIGN UTERINE DISEASE
良性子宫疾病的光动力治疗
批准号:
6182538
负责人:
Bruce J. Tromberg
金额:
$18.3万
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-07-03 至 2003-06-30

项目摘要

项目成果

Bruce J. Tromberg的其他基金

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中文摘要
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英文摘要
DESCRIPTION: The long-term goal of the proposed work is to develop a new, minimally-invasive treatment of benign uterine disease based on Photodynamic Therapy (PDT). Eventually, uterine PDT may have a significant impact on women's health care and its associated costs because it will provide an inexpensive, outpatient alternative to conventional surgical and medical techniques for treating dysfunctional uterine bleeding (DUB) and improving adenomyosis (AM)-related symptoms. During the past six years we have completed a number of animal, human and modeling studies that have helped us understand the complexity inherent to achieving irreversible endometrial ablation (EA) during PDT. We now propose a major new effort which builds on this foundation and further characterizes how light and drug dosimetry parameters affect clinical outcome. Specific aims include: 1) constructing, characterizing and optimizing performance of a novel, minimally-invasive intrauterine light probe (IULP); 2) completing Phase I/II and beginning Phase III human clinical trials with ALA; 3) testing a limited number of new sensitizers in animal models; and 4) evaluating pharmacokinetics, safety and efficacy of a limited number of new compounds in humans.
期刊论文(3)
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会议论文
Intrauterine light probe for photodynamic ablation therapy.
用于光动力消融治疗的宫内光探头。
DOI: --
发表时间: 1999
期刊: Obstetrics and gynecology
影响因子: 7.2
作者: [Tadir,Y, Hornung,R, Pham,TH, Tromberg,BJ]
通讯作者: Tromberg,BJ
Imaging Core
  • 批准号:
    10385796
  • 项目类别:
  • 资助金额:
    $18.35万
  • 财政年份:
    2019
  • 负责人:
    Bruce J. Tromberg
  • 依托单位:
Imaging Core
  • 批准号:
    10618813
  • 项目类别:
  • 资助金额:
    $17.03万
  • 财政年份:
    2019
  • 负责人:
    Bruce J. Tromberg
  • 依托单位:
Imaging Core
  • 批准号:
    10199935
  • 项目类别:
  • 资助金额:
    $18.65万
  • 财政年份:
    2019
  • 负责人:
    Bruce J. Tromberg
  • 依托单位:
Optical Tomography of Intrinsic Signals in Rat Cortex
  • 批准号:
    8285930
  • 项目类别:
  • 资助金额:
    $22.14万
  • 财政年份:
    2012
  • 负责人:
    Bruce J. Tromberg
  • 依托单位: