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A method for simultaneous measurements of cerebral blood flow and cerebral metabolic rate for oxygen by magnetic resonance imaging.

一种通过磁共振成像同时测量脑血流量和脑氧代谢率的方法。

基本信息

批准号：
07557178
负责人：
ARAI Toshiyuki
金额：
$ 10.3万
依托单位：
KYOTO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

项目摘要

A method for simultaneous measurements of cerebral blood flow (CBF) and cerebral metabolic rate for oxygen (CMRo_2) by magnetic resonance imaging (MRI) was developed.First, CBF was measured in cats by MRI,using ^<17>O-labeled water (water-17) as a tracer. Cat brain images were obtained using a fast spin-echo sequence. Intravenous infusion of water-17 and collection of a series of arterial blood samples were simultaneously performed during the MRI scan. From changes in brain signal intensity induced by water-17 infusion, water-17 concentration of brain were calculared. Water-17 concentration in arterial blood was measured directly by ^<17>O NMR spectroscopy. From these data, CBF was successfully determined using an in vivo autoradiographic strategy.Next, CBF and CMRo_2 were measured simultaneously in cats by MRI,using ^<17>O-labeled oxygen gas (oxygen-17 gas) as a tracer. Cat brain images were obtained using a fast spin-echo sequence. During inhalation of oxygen-17 gas, a series of MRI scans and arterial blood samplings were performed. From changes in brain signal intensity induced by oxygen-17 inhalation, metabolic water-17 concentration of brain were calculated. Metabolic water-17 concentration in arterial blood was measured directly by ^<17>O NMR spectroscopy. Applying convolution integral and least square method, CBF and CMRo_2 were simultaneously calculated from these data. However, the obtained values were not sufficient as reasonable values. To resolve this problem, changes in signal intensity, induced by oxygen-17 gas inhalation, should be detected much more sensitively by MRI.

建立了一种同时测量脑血流量(CBF)和脑氧代谢率(CMRO2)的磁共振成像(MRI)方法。猫脑图像是使用快速自旋回波序列获得的。在MRI扫描期间，同时进行静脉输注水-17和采集一系列动脉血样本。根据注射水-17引起的脑信号强度的变化，计算脑内水-17的浓度。用核磁共振波谱直接测定动脉血中水-17的浓度。根据这些数据，采用体内放射自显影技术成功地测定了猫的脑血流量。接下来，使用^&lt；17&gt；O标记的氧气(氧-17气体)作为示踪剂，用MRI同时测量了猫的脑血流量和CMRO2。猫脑图像是使用快速自旋回波序列获得的。在吸入氧气-17气体的过程中，进行了一系列的MRI扫描和动脉采血。根据吸入氧-17引起的脑信号强度变化，计算脑内代谢水-17浓度。用核磁共振波谱直接测定动脉血中代谢水-17的浓度。应用卷积积分和最小二乘法同时计算CBF和CMRO2。然而，所获得的值并不足以作为合理的值。为了解决这个问题，吸入氧-17气体引起的信号强度变化应该通过MRI更灵敏地检测出来。